Shrimali R G, Patel M D, Patel R M
Department of Veterinary Medicine, College of Veterinary Science & Animal Husbandry, Navsari Agricultural University, Navsari - 396 450, Gujarat, India.
Vet World. 2016 May;9(5):524-9. doi: 10.14202/vetworld.2016.524-529. Epub 2016 May 28.
Fasciolosis is a parasitic disease caused by Fasciola spp. of the family Fasciolidae (trematodes) characterized by bottle jaw, anemia, progressive debility, and potbelly condition. There are many aspects of fasciolosis remaining unknown thus hemato-biochemical alterations in closantel, triclabendazole + ivermectin, and oxyclozanide + levamisole treated goats were studied.
A total of 40 naturally fasciolosis infected goats having egg per gram more than 100 were randomly divided into four groups. Goats of Group I-III were treated with three different anthelmintics, whereas, goats of Group-IV were kept as control or untreated. Whole blood, serum, and fecal samples were collected on 0, 7(th), and 30(th) day of treatment.
During the study, values of hemoglobin, total erythrocyte count, pack cell volume, and total protein were significantly elevated to their normal levels in anthelmintics treated groups. Whereas, values of total leukocyte count, aspartate transaminase (AST), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT) were significantly reduced to their normal level in anthelmintics treated groups. The efficacy of closantel (T1), triclabendazole + ivermectin (T2), and oxyclozanide + levamisole (T3) was 99.63%, 100%, and 94.74% and 100%, 100%, and 97.38% on 7(th) and 30(th) day of treatment, respectively.
Fasciolosis in goats can be diagnosed on the basis of fecal sample examination, but alterations in important biomarkers such as AST, GGT, and LDH are also helpful for early diagnosis. The use of newer anthelmintic either alone or in combination showed a higher therapeutic response in fasciolosis of goats.
肝片吸虫病是由片形科（吸虫）的片形吸虫属引起的一种寄生虫病，其特征为下颌水肿、贫血、进行性衰弱和大肚症。肝片吸虫病仍有许多方面尚不清楚，因此对氯氰碘柳胺、三氯苯达唑+伊维菌素以及羟氯扎胺+左旋咪唑治疗山羊后的血液生化改变进行了研究。
将40只自然感染肝片吸虫病且每克粪便虫卵数超过100的山羊随机分为四组。第一至三组的山羊用三种不同的驱虫药进行治疗，而第四组的山羊作为对照或不进行治疗。在治疗的第0、7和30天采集全血、血清和粪便样本。
在研究期间，驱虫药治疗组的血红蛋白、总红细胞计数、血细胞比容和总蛋白值显著升高至正常水平。而驱虫药治疗组的白细胞总数、天冬氨酸转氨酶（AST）、乳酸脱氢酶（LDH）和γ-谷氨酰转移酶（GGT）值显著降低至正常水平。氯氰碘柳胺（T1）、三氯苯达唑+伊维菌素（T2）和羟氯扎胺+左旋咪唑（T3）在治疗第7天和第30天的疗效分别为99.63%、100%和94.74%以及100%、100%和97.38%。
山羊肝片吸虫病可通过粪便样本检查进行诊断，但AST、GGT和LDH等重要生物标志物的改变也有助于早期诊断。单独或联合使用新型驱虫药对山羊肝片吸虫病显示出更高的治疗反应。
