Miyamoto M, Sudo T, Kuyama T, Kawamura M, Ishiyama K, Tsubakimoto R, Fukunishi K, Bessho H, Yasuda C, Uchida T
Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
Nihon Geka Hokan. 1990 May 1;59(3):263-71.
Unexplained serum creatine phosphokinase (CPK) elevation is not a rare clinical problem, especially in emergency diseases. We studied hypercreatine phosphokinasemia (hyper-CPK-emia) in 161 cases of emergency diseases. Correlations between CPK and various laboratory data, various conditions were investigated. The hyper-CPK-emia was found to obtain no correlations with GPT, GOT, LDH, creatinine and body temperature. For this reason, we could not discover the unknown factors of which contributed to elevate the serum CPK. The sources of the serum CPK in these diseases were concluded to be the skeletal muscle. This is based on the facts that CPK MM (muscle type) is specifically increased among the CPK isozymes. The elevation of serum CPK activity in emergency diseases was considered to result from muscle hypoxia due to severe stress and general circulatory failure.
不明原因的血清肌酸磷酸激酶（CPK）升高并非罕见的临床问题，尤其是在急诊疾病中。我们对161例急诊疾病患者的高肌酸磷酸激酶血症（高CPK血症）进行了研究。调查了CPK与各种实验室数据、各种情况之间的相关性。发现高CPK血症与谷丙转氨酶（GPT）、谷草转氨酶（GOT）、乳酸脱氢酶（LDH）、肌酐和体温均无相关性。因此，我们无法发现导致血清CPK升高的未知因素。这些疾病中血清CPK的来源被认为是骨骼肌。这是基于以下事实：在CPK同工酶中，CPK-MM（肌肉型）特异性增加。急诊疾病中血清CPK活性的升高被认为是由于严重应激和全身循环衰竭导致的肌肉缺氧所致。
