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一名5岁叙利亚女性腹部结核患者出现癫痫发作的罕见病例：异烟肼治疗剂量的副作用。

An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect.

作者信息

Mohammad Lava, Doya Leen, Omran Razan, Ibrahim Alexander, Alshehabi Zuheir, Ibrahim Ali

机构信息

Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria.

Department of Internal Medicine, Tishreen University Hospital, Lattakia, Syria.

出版信息

Oxf Med Case Reports. 2021 Jan 23;2021(1):omaa126. doi: 10.1093/omcr/omaa126. eCollection 2021 Jan.

DOI:10.1093/omcr/omaa126
PMID:33542828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7846128/
Abstract

Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a case of a 5-year-old girl with intestinal Tuberculosis, who developed hemiclonic seizure as a side effect of INH therapeutic dose after 2 weeks of tuberculosis therapy.

摘要

异烟肼（INH）对正在复制的结核杆菌具有高度杀菌作用，并且参与所有抗结核化疗方案。文献中已有报道，成人在治疗性使用和过量使用INH后会出现几种神经方面的不良反应。在此，我们报告一例5岁患肠结核的女孩，在抗结核治疗2周后，出现半侧阵挛性癫痫发作，这是INH治疗剂量产生的副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/c2d536b06e12/omaa126f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/590df73dc991/omaa126f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/510be9c74e71/omaa126f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/ab7afc47f8df/omaa126f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/c2d536b06e12/omaa126f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/590df73dc991/omaa126f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/510be9c74e71/omaa126f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/ab7afc47f8df/omaa126f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/7846128/c2d536b06e12/omaa126f4.jpg

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1
An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect.一名5岁叙利亚女性腹部结核患者出现癫痫发作的罕见病例：异烟肼治疗剂量的副作用。
Oxf Med Case Reports. 2021 Jan 23;2021(1):omaa126. doi: 10.1093/omcr/omaa126. eCollection 2021 Jan.
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U.S. Public Health Service Cooperative trial of three rifampin-isoniazid regimens in treatment of pulmonary tuberculosis.美国公共卫生服务局关于三种利福平-异烟肼治疗方案治疗肺结核的合作试验。
Am Rev Respir Dis. 1979 Jun;119(6):879-94. doi: 10.1164/arrd.1979.119.6.879.

本文引用的文献

1
Index-TB guidelines: Guidelines on extrapulmonary tuberculosis for India.索引-TB 指南：印度肺外结核指南。
Indian J Med Res. 2017 Apr;145(4):448-463. doi: 10.4103/ijmr.IJMR_1950_16.
2
Abdominal Tuberculosis.腹部结核
J Assoc Physicians India. 2016 Feb;64(2):38-47.
3
Treatment of Tuberculosis. A Historical Perspective.结核病的治疗：历史视角
Ann Am Thorac Soc. 2015 Dec;12(12):1749-59. doi: 10.1513/AnnalsATS.201509-632PS.
4
Convulsive seizures with a therapeutic dose of isoniazid.使用治疗剂量异烟肼引发的惊厥性癫痫发作。
Intern Med. 2014;53(3):239-42. doi: 10.2169/internalmedicine.53.1303.
5
Seizures with single therapeutic dose of isoniazid.单次治疗剂量异烟肼所致癫痫发作
Indian J Tuberc. 2012 Apr;59(2):100-2.
6
Abdominal tuberculosis in children: a diagnostic challenge.儿童腹腔结核病：诊断难题。
J Microbiol Immunol Infect. 2010 Jun;43(3):188-93. doi: 10.1016/S1684-1182(10)60030-8.
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Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy.
Pediatr Emerg Care. 2010 May;26(5):380-1. doi: 10.1097/PEC.0b013e3181db24b6.
8
Clinical, endoscopic, and histological differentiations between Crohn's disease and intestinal tuberculosis.克罗恩病与肠结核的临床、内镜和组织学鉴别。
Am J Gastroenterol. 2010 Mar;105(3):642-51. doi: 10.1038/ajg.2009.585. Epub 2010 Jan 19.