ASST Santi Paolo e Carlo, Presidio Ospedaliero San Paolo, Odontostomatologia II Clinical Unit, Milan, Italy.
Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milan, Italy.
Spec Care Dentist. 2021 May;41(3):417-422. doi: 10.1111/scd.12574. Epub 2021 Feb 5.
Undifferentiated pleomorphic sarcoma (UPS), also defined malignant fibrous histiocytoma (MFH), is one of the most common sarcomas affecting soft tissues in adults, but it can also arise as a primary tumor in bone. UPS is extremely uncommon in the lower jaw and presents very aggressive clinical behavior with high rate of local recurrences and frequent metastases. Secondary UPS are even rarer than primary forms, and they are usually closely associated with local trauma or radiotherapy. This case report aims at illustrating a rare case of secondary UPS of the mandible in an 81-year-old male affected by HIV, maxillary oral squamous cell carcinoma (and mandibular recurrence), and who underwent head and neck radiotherapy. The complete immunohistochemical pattern of the lesion is reported. Due to his medical history and systemic status, the patient has been considered not eligible for further surgical procedures nor radiotherapy. Therefore, a palliative care treatment has been scheduled.
未分化多形性肉瘤（UPS），也称为恶性纤维组织细胞瘤（MFH），是成人软组织中最常见的肉瘤之一，但也可作为骨原发性肿瘤发生。UPS 在下颌骨中极为罕见，表现出非常侵袭性的临床行为，局部复发率高，且常发生转移。继发性 UPS 比原发性更为罕见，且通常与局部创伤或放射治疗密切相关。本病例报告旨在说明一例罕见的 81 岁男性 HIV 患者下颌骨继发性 UPS 病例，该患者患有上颌口腔鳞状细胞癌（及下颌骨复发），并接受了头颈部放射治疗。报道了病变的完整免疫组化模式。由于其病史和全身状况，该患者被认为不适合进一步手术或放疗。因此，已安排姑息治疗。
