Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russian Federation.
Institute of Biology of Komi Science Center, Ural Branch of RAS, 167982, Syktyvkar, Russian Federation.
Biogerontology. 2021 Apr;22(2):197-214. doi: 10.1007/s10522-021-09911-4. Epub 2021 Feb 5.
Endogenous hydrogen sulfide (HS) is a gasotransmitter with a wide range of physiological functions. Aging is accompanied by disruption of HS homeostasis, therefore, interventions to the processes of HS metabolism to maintain its balance may have geroprotective potential. Here we demonstrated the additive geroprotective effect of combined genetic and pharmacological interventions to the hydrogen sulfide biosynthesis system by overexpression of cystathionine-β-synthase and cystathionine-γ-lyase genes and treatment with precursors of HS synthesis cysteine (Cys) and N-acetyl-L-cysteine (NAC). The obtained results suggest that additive effects of genetic and pharmacological interventions to HS metabolism may be associated with the complex interaction between beneficial action of HS production and prevention of adverse effects of excess HS production by Cys and NAC treatment.
内源性硫化氢 (HS) 是一种具有广泛生理功能的气体递质。衰老伴随着 HS 动态平衡的破坏，因此，干预 HS 代谢过程以维持其平衡可能具有抗衰老的潜力。在这里，我们通过过表达半胱氨酸-β-合酶和半胱氨酸-γ-裂合酶基因以及用 HS 合成前体半胱氨酸 (Cys) 和 N-乙酰-L-半胱氨酸 (NAC) 治疗，证明了联合遗传和药理学干预 HS 生物合成系统的附加抗衰老作用。研究结果表明，HS 代谢的遗传和药理学干预的相加作用可能与 HS 产生的有益作用与 Cys 和 NAC 处理防止过量 HS 产生的不利影响之间的复杂相互作用有关。
