Overexpression of and genes affects lifespan, stress resistance and locomotor activity in .

Recent experimental studies highlighted the role of hydrogen sulfide (HS) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for HS production. Here we investigated the geroprotective effects of and overexpression in . Overexpression of did not affect a lifespan and decrease (mitochondrial form of ) or increase (cytoplasmic form of ) age dynamics of locomotor activity, while overexpression of increase median (by 12.5%) and maximum (by 6.9%) lifespan and locomotor activity. Increasing of both and expression levels resulted in thermotolerance, but the resistance to combination of arid and food-free conditions decreased. The resistance to oxidative stress (paraquat) was not affected in flies with overexpression of and cytoplasmic , but decreased in flies overexpressing mitochondrial form of . Thus, transgene overexpression of the and in induce similar effects on stress-resistance and locomotor activity, however lifespan extending effect was revealed for overexpression only.