Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri UNITED STATES.
Biomol Concepts. 2021 Jan 29;12(1):1-7. doi: 10.1515/bmc-2021-0001.
The advent of genome editing technology promises to transform human health, livestock and agriculture, and to eradicate pest species. This transformative power demands urgent scrutiny and resolution of the ethical conflicts attached to the creation and release of engineered genomes. Here, I discuss the ethics surrounding the transformative CRISPR/Cas9-mediated genome editing technology in the contexts of human genome editing to eradicate genetic disease and of gene drive technology to eradicate animal vectors of human disease.
基因组编辑技术的出现有望改变人类健康、畜牧业和农业，并消灭害虫物种。这种变革性的力量要求对与工程基因组的创建和释放相关的伦理冲突进行紧急审查和解决。在这里，我将讨论围绕着 CRISPR/Cas9 介导的基因组编辑技术在消除遗传疾病的人类基因组编辑和消除人类疾病的动物载体的基因驱动技术的背景下的伦理问题。
