Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, D-69120Heidelberg, Germany.
Biol Chem. 2020 Nov 4;402(1):7-23. doi: 10.1515/hsz-2020-0270. Print 2020 Nov 18.
The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, post-transcriptional regulators, and critical cofactors of piRNA-mediated transcript silencing.
LOTUS 结构域（也称为 OST-HTH）是一种在多种细菌和真核生物中发现的高度保守的蛋白质结构域。在动物中，LOTUS 结构域存在于 Oskar、TDRD5/Tejas、TDRD7/TRAP/Tapas 和 MARF1/Limkain B1 等蛋白质中，它们在动物发育中发挥着重要作用，特别是在卵子发生和/或精子发生过程中。本文综述了 LOTUS 结构域蛋白的多种生物学和分子功能，并讨论了它们作为解旋酶效应物、转录后调控因子以及 piRNA 介导的转录沉默的关键辅助因子的作用。
