School of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY 42101, USA.
School of Nursing and Allied Health, Western Kentucky University, Bowling Green, KY 42101, USA.
Appl Physiol Nutr Metab. 2021 Apr;46(4):404-407. doi: 10.1139/apnm-2020-1005. Epub 2021 Feb 5.
The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of "metabolic flexibility". Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility ( = -0.271, = 0.034), maternal HOMA-IR ( = 0.280, = 0.030), and maternal body mass index ( = 0.299, = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319. This is the first study to link maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy to neonatal adiposity at parturition.
本研究旨在确定孕妇怀孕期间代谢灵活性与新生儿健康结果之间的关系。脂氧化的百分比变化（高脂肪餐后和之前）被计算为“代谢灵活性”的衡量标准。通过皮褶人体测量法在分娩后 48 小时内评估新生儿肥胖程度。代谢灵活性（=-0.271，=0.034）、母体 HOMA-IR（=0.280，=0.030）和母体体重指数（=0.299，=0.018）与新生儿肩胛下皮褶（即新生儿肥胖的衡量标准）相关。临床试验注册号：NCT03504319。这是第一项将孕妇怀孕期间的代谢灵活性、体重指数和胰岛素抵抗与分娩时的新生儿肥胖联系起来的研究。
