Katragadda Tejasree, Mahabala Rajesh Shimoga, Shetty Subodh, Baliga Shantharam
Resident, Department of Paediatrics, Kasturba Medical College , Mangaluru, Karnataka, India .
Associate Professor, Department of Paediatrics, Kasturba Medical College , Mangaluru, Karnataka, India .
J Clin Diagn Res. 2017 Jan;11(1):SC05-SC07. doi: 10.7860/JCDR/2017/24247.9197. Epub 2017 Jan 1.
Coronary heart disease is one of the major causes of morbidity and mortality in current era. The roots of this epidemic have been traced to as early as foetal life by foetal origin hypothesis. There are a few studies which have compared the cord blood lipid profile of preterm and term babies and thereby leading a path to primordial prevention of chronic diseases.
To study cord blood lipid profile of preterm appropriate for gestational age and preterm small for gestational age neonates and compare atherogenic index of both groups.
This cross-sectional study was conducted in 109 preterm infants. Cord blood samples were collected from placental side of umbilical cord at birth and analyzed for lipid profile which includes serum cholesterol, triglycerides, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and apolipoproteins which include ApoA1, Apo B.
Preterm Small for Gestational Age (SGA) neonates had statistically significant higher values of triglycerides, Apo B and atherogenic index compared to preterm Appropriate for Gestational Age (AGA) neonates. Other measured lipid levels were not statistically significant, though the values were higher than reference ranges for term babies.
Prematurity as a factor associated with a more atherogenic lipid profile is re-affirmed and SGA as an additional risk factor has been proven giving scope for future research and primordial prevention.
冠心病是当代发病和死亡的主要原因之一。胎儿起源假说认为，这种流行病的根源可追溯到胎儿期。有一些研究比较了早产和足月婴儿的脐血脂谱，从而为慢性病的初级预防开辟了道路。
研究适于胎龄早产和小于胎龄早产新生儿的脐血脂谱，并比较两组的动脉粥样硬化指数。
对109例早产儿进行了这项横断面研究。出生时从脐带胎盘侧采集脐血样本，分析血脂谱，包括血清胆固醇、甘油三酯、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）以及载脂蛋白，包括载脂蛋白A1、载脂蛋白B。
与适于胎龄（AGA）早产新生儿相比，小于胎龄（SGA）早产新生儿的甘油三酯、载脂蛋白B和动脉粥样硬化指数在统计学上有显著更高的值。其他测量的血脂水平虽高于足月婴儿的参考范围，但无统计学意义。
早产作为与动脉粥样硬化性更强的血脂谱相关的一个因素得到再次确认，SGA作为一个额外的危险因素已得到证实，为未来的研究和初级预防提供了空间。
