Amédée-Manesme O, Mourey M S, Therasse J, Couturier M, Alvarez F, Hanck A, Bernard O
Département de Pédiatrie, Hôpital de Bicêtre, Le Kremlin, France.
Am J Clin Nutr. 1988 Apr;47(4):690-3. doi: 10.1093/ajcn/47.4.690.
Newborns have limited reserve supplies of vitamin A. Infants with chronic cholestasis are in a precarious nutritional state because of their limited ability to build these stores even though the vitamin is present in their diet. In this study, we investigated liver concentrations of vitamin A in 30 children with extrahepatic biliary atresia. We demonstrate that correction of the deficiency occurs after intramuscular administration of a water-miscible solution of retinyl palmitate (100,000 IU, or 30 mg retinol equivalent). Furthermore, we evaluated the effect of vitamin A injections on liver and blood concentrations in nine children with chronic cholestasis over a 1-y period. We conclude this treatment is efficient and is well tolerated.
新生儿的维生素A储备供应有限。患有慢性胆汁淤积症的婴儿处于不稳定的营养状态，因为即使其饮食中含有维生素，他们储存维生素的能力也有限。在本研究中，我们调查了30例肝外胆道闭锁患儿肝脏中的维生素A浓度。我们证明，肌肉注射水溶性棕榈酸视黄酯溶液（100,000 IU，或30 mg视黄醇当量）后，维生素A缺乏得到纠正。此外，我们评估了1年内维生素A注射对9例慢性胆汁淤积症患儿肝脏和血液中维生素A浓度的影响。我们得出结论，这种治疗有效且耐受性良好。
