Amédée-Manesme O, Furr H C, Alvarez F, Hadchouel M, Alagille D, Olson J A
Hepatology. 1985 Nov-Dec;5(6):1143-8. doi: 10.1002/hep.1840050614.
Biochemical indicators of vitamin A status were measured in 24 children (1 month to 6 years old) with severe cholestasis starting early in life and in 21 children (3 months to 13 years old) with liver disease but without cholestasis. Liver vitamin A concentrations, expressed as micrograms of retinol per gram of liver (mean +/- S.D.), were 6.3 +/- 7.1 (range: 0.14 to 28) and 143 +/- 108 (range: 18 to 424), respectively, in cholestatic and non-cholestatic children. In infants less than 6 months of age, liver vitamin A values less than 10 micrograms per gm were found in 14 of 17 cholestatic children but in none of 3 non-cholestatic subjects. Plasma vitamin A values, expressed as micrograms of retinol per deciliter (mean +/- S.D.), were 23 +/- 18 (range: 3 to 62) and 46 +/- 33 (range: 14 to 125), respectively, for the two groups. Plasma retinol values less than 10 micrograms per dl were always associated with liver concentrations less than 10 micrograms per gm. Plasma retinol-binding protein was only reduced to 71% of control values in cholestatic children. The fatty acid composition of liver retinyl esters was unaffected by any condition studied. Infants with chronic cholestasis are in a precarious nutritional status very early in life relative to liver reserves of vitamin A. Plasma vitamin A values, unless less than 10 micrograms retinol per dl, are poor indicators of inadequate vitamin A status.
对24名（1个月至6岁）自幼起就患有严重胆汁淤积症的儿童以及21名（3个月至13岁）患有肝病但无胆汁淤积症的儿童，测量了维生素A状态的生化指标。胆汁淤积症儿童和非胆汁淤积症儿童肝脏中的维生素A浓度，以每克肝脏中视黄醇的微克数表示（平均值±标准差），分别为6.3±7.1（范围：0.14至28）和143±108（范围：从18至424）。在6个月以下的婴儿中，17名胆汁淤积症儿童中有14名肝脏维生素A值低于每克10微克，而3名非胆汁淤积症儿童中无一例低于此值。两组的血浆维生素A值，以每分升视黄醇的微克数表示（平均值±标准差），分别为为23±18（范围：3至62）和46±33（范围：14至125）。血浆视黄醇值低于每分升10微克总是与肝脏浓度低于每克10微克相关。在胆汁淤积症儿童中，血浆视黄醇结合蛋白仅降至对照值的71%。肝脏视黄酯的脂肪酸组成不受所研究的任何条件影响。相对于肝脏中的维生素A储备，患有慢性胆汁淤积症的婴儿在生命早期就处于不稳定的营养状态。血浆维生素A值，除非低于每分升10微克视黄醇，否则不能很好地指示维生素A状态不足。
