Fukui Y, Okada A, Kawahara H, Imura K, Kamata S, Kimura S, Harada T
Department of Pediatric Surgery, Osaka University Medical School, Japan.
J Pediatr Surg. 1993 Nov;28(11):1502-4. doi: 10.1016/0022-3468(93)90441-m.
The vitamin A status of 19 patients with corrected biliary atresia was examined. They had been receiving 5,000 IU of oral vitamin A daily postoperatively. Plasma vitamin A levels in the nonjaundiced group were almost within normal range, whereas those in the jaundiced group were significantly low compared with the controls. In the oral vitamin A tolerance test, plasma vitamin A levels increased from 33.1 +/- 11.8 to 215.4 +/- 100.7 micrograms/dL in the nonjaundiced group, and from 23.1 +/- 10.3 to 209.8 +/- 154.2 micrograms/dL in the slightly jaundiced group, at 4 hours after the administration of vitamin A, showing no difference between both group and control. In the severely jaundiced group, plasma vitamin A levels increased from 13.5 +/- 3.5 to 30.0 +/- 14.6 micrograms/dL, a significantly smaller increase compared with controls. However, liver vitamin A levels were greater than 20 micrograms/g liver in all patients, irrespective of the presence of jaundice. This study suggested that nutritional support to facilitate the synthesis of retinol-binding protein may be an important factor in addition to vitamin A supplementation.
对19例矫正型胆道闭锁患者的维生素A状况进行了检查。他们术后每天接受5000国际单位的口服维生素A。非黄疸组的血浆维生素A水平几乎在正常范围内，而黄疸组的血浆维生素A水平与对照组相比显著降低。在口服维生素A耐量试验中，维生素A给药后4小时，非黄疸组的血浆维生素A水平从33.1±11.8微克/分升升至215.4±100.7微克/分升，轻度黄疸组从23.1±10.3微克/分升升至209.8±154.2微克/分升，两组与对照组之间无差异。在重度黄疸组中，血浆维生素A水平从13.5±3.5微克/分升升至30.0±14.6微克/分升，与对照组相比升高明显较小。然而，无论有无黄疸，所有患者肝脏中的维生素A水平均大于20微克/克肝脏。该研究表明，除补充维生素A外，促进视黄醇结合蛋白合成的营养支持可能是一个重要因素。
