Department of Pharmacy, School of Health Sciences, University of Patras, Rion-Patras, Greece.
Department of Pharmacognosy-Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Exp Dermatol. 2021 May;30(5):628-644. doi: 10.1111/exd.14299. Epub 2021 Feb 15.
Skin appearance is essential for self-esteem and quality of life; consequently, skin care products represent a huge market. In particular, cosmeceuticals constitute a hybrid category of skin care formulations, at the interphase of cosmetics and pharmaceuticals, rationally designed to target (patho) physiological mechanisms aiming to enhance skin health and appearance. Cosmeceuticals are marketed as anti-ageing, anti-wrinkle, hair regrowth, skin whitening and wound healing agents with special emphasis on scar-free healing. An overview on recent cutting-edge advances concerning the discovery and development of enhanced performance cosmeceuticals by drug repositioning approaches is presented here. In this context, we propose "target repositioning," a new term, to highlight that druggable protein targets implicated in multiple diseases (hubs in the diseasome) can be exploited to accelerate the discovery of molecularly targeted cosmeceuticals that can promote skin health as an added benefit, which is a novel concept not described before. In this direction, emphasis is placed on the role of mouse models, for often untreatable skin diseases, as well as recent breakthroughs on monogenic rare skin syndromes, in promoting compound repositioning to innovative cosmeceuticals.
皮肤外观对自尊和生活质量至关重要；因此，护肤品市场巨大。特别是，药妆品是介于化妆品和药品之间的一种混合类别，其配方经过合理设计，针对（病理）生理机制，旨在增强皮肤健康和外观。药妆品被宣传为抗衰老、抗皱、生发、皮肤美白和伤口愈合剂，特别强调无疤痕愈合。本文概述了通过药物重定位方法发现和开发增强性能药妆品的最新前沿进展。在这方面，我们提出了“靶向重定位”这一新术语，以强调涉及多种疾病的可成药蛋白靶标（疾病组中的枢纽）可被利用来加速发现分子靶向药妆品，这些药妆品可促进皮肤健康，这是一个以前未描述过的新概念。在这方面，强调了小鼠模型在治疗许多皮肤疾病方面的作用，以及单基因罕见皮肤综合征的最新突破，这些突破促进了化合物向创新药妆品的重新定位。
