Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Arthritis Care Res (Hoboken). 2022 Aug;74(8):1277-1286. doi: 10.1002/acr.24576. Epub 2022 Apr 30.
Gout and hyperuricemia incidence is increasing worldwide, reflecting pandemic overweight and obesity. However, the magnitude of the association of body mass index (BMI) changes with serum uric acid (UA) level in the general population has remained unevaluated.
This retrospective cohort study enrolled 27,422 Korean men who underwent a comprehensive health check-up between 2015 and 2017. BMI change was categorized into 7 groups. The relationship between BMI change and serum UA level alteration was determined using multivariable regression models.
The mean age, BMI, and serum UA level were 38.8 years, 24.7 kg/m , and 6.2 mg/dl, respectively. All BMI change categories had a clear dose-response relationship with the serum UA level changes. The corresponding β coefficient of serum UA level changes was 0.13 (95% confidence interval [95% CI] 0.11, 0.16), 0.25 (95% CI 0.2, 0.3), and 0.44 (95% CI 0.36, 0.52) for a BMI decrease of 0.5-1.5, 1.5-2.5, and ≥2.5, respectively. Compared with no BMI change, the multivariate odds ratios of achieving normouricemia for a BMI increase of 0.5-1.5, 1.5-2.5, and ≥2.5 were 0.88 (95% CI 0.83, 0.95), 0.67 (95% CI 0.60, 0.75), and 0.60 (95% CI 0.49, 0.74), whereas those for a BMI decrease of 0.5-1.5, 1.5-2.5, and ≥2.5 were 1.17 (95% CI 1.07, 1.27), 1.28 (95% CI 1.08, 1.52), and 1.46 (95% CI 1.13, 1.88), respectively.
BMI change could have a significant association with the alteration of serum UA levels of apparently healthy men. Despite its small effect size, the health risks and benefits of BMI change would be emphasized for serum UA level alteration.
痛风和高尿酸血症的发病率在全球范围内呈上升趋势，这反映了超重和肥胖的流行。然而，体重指数（BMI）变化与普通人群血清尿酸（UA）水平之间的关联程度仍未得到评估。
本回顾性队列研究纳入了 2015 年至 2017 年间接受全面健康检查的 27422 名韩国男性。BMI 变化分为 7 组。使用多变量回归模型确定 BMI 变化与血清 UA 水平变化之间的关系。
平均年龄、BMI 和血清 UA 水平分别为 38.8 岁、24.7kg/m 和 6.2mg/dl。所有 BMI 变化类别均与血清 UA 水平变化呈明显的剂量反应关系。血清 UA 水平变化的相应β系数分别为 0.13（95%置信区间[95%CI]0.11，0.16）、0.25（95%CI0.20，0.30）和 0.44（95%CI0.36，0.52），对应 BMI 降低 0.5-1.5、1.5-2.5 和≥2.5。与 BMI 无变化相比，BMI 增加 0.5-1.5、1.5-2.5 和≥2.5 时达到正常尿酸血症的多变量优势比分别为 0.88（95%CI0.83，0.95）、0.67（95%CI0.60，0.75）和 0.60（95%CI0.49，0.74），而 BMI 降低 0.5-1.5、1.5-2.5 和≥2.5 时的优势比分别为 1.17（95%CI1.07，1.27）、1.28（95%CI1.08，1.52）和 1.46（95%CI1.13，1.88）。
BMI 变化与明显健康男性血清 UA 水平的变化具有显著相关性。尽管其影响程度较小，但鉴于 BMI 变化对血清 UA 水平的影响，应强调 BMI 变化对健康的风险和益处。
