Gao Yan, Han Dong, Feng Juan
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Clin Chim Acta. 2021 May;516:92-99. doi: 10.1016/j.cca.2021.01.020. Epub 2021 Feb 2.
Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS). Despite a complex pathogenesis, it appears that an imbalanced immune system plays an important role in the disease process. MicroRNAs (miRNAs) are comprised of short non-coding single-stranded molecules mainly involved in regulating gene expression through the inhibition of transcription and translation. miRNAs are key regulatory molecules in the nucleus and participate in the proliferation, differentiation, and apoptosis of various cells throughout the body. Recent studies, however, have found that miRNAs are also involved in MS pathogenesis, mainly affecting glial cells and peripheral immune cells. Fortunately, miRNAs are highly stable and have high specificity in peripheral body fluids. Accordingly, these molecules have become new diagnostic and therapeutic targets. The present review discusses the role of miRNAs in the pathogenesis of MS. We highlight the potential of miRNAs as new biomarkers of MS and potential therapeutic agents.
多发性硬化症（MS）是一种影响中枢神经系统（CNS）的自身免疫性疾病。尽管其发病机制复杂，但免疫系统失衡似乎在疾病过程中起着重要作用。微小RNA（miRNA）由短的非编码单链分子组成，主要通过抑制转录和翻译来调节基因表达。miRNA是细胞核中的关键调节分子，参与全身各种细胞的增殖、分化和凋亡。然而，最近的研究发现，miRNA也参与MS的发病机制，主要影响神经胶质细胞和外周免疫细胞。幸运的是，miRNA在外周体液中高度稳定且具有高特异性。因此，这些分子已成为新的诊断和治疗靶点。本综述讨论了miRNA在MS发病机制中的作用。我们强调了miRNA作为MS新生物标志物和潜在治疗药物的潜力。
