Universidad de las Américas Puebla, San Andrés Cholula, PUE, México; Centro de Hematología y Medicina Interna, Clínica RUIZ, PUE, Méixico.
Centro de Hematología y Medicina Interna, Clínica RUIZ, PUE, Méixico; Universidad Popular Autónoma del Estado de Puebla, PUE, México.
Mult Scler Relat Disord. 2022 Jul;63:103835. doi: 10.1016/j.msard.2022.103835. Epub 2022 Apr 30.
Micro-RNAs (miRNAs) are noncoding, single stranded segments of RNA measuring 19 to 25 nucleotides in length. They play an active role in autoimmune diseases, including multiple sclerosis (MS). These structures have been studied given their implication in the process of diagnosis, disease development, treatment and prognosis of MS. Given the progressive and neurodegenerative nature of MS, miRNAs have been identified as critical mediators and molecular pinpoints of the disease, which poses them as excellent candidates for the obtention of suitable biomarkers and treatment targets. This review condenses recent findings on the role of miRNAs in multiple sclerosis, including their role in MS etiology and molecular mechanisms of the disease, exploitation of miRNAs as diagnostic tools and biomarkers, miRNAs as treatment option or target for MS, and their significance as predictors of disease prognosis.
微小 RNA（miRNA）是长度为 19 到 25 个核苷酸的非编码、单链 RNA 片段。它们在自身免疫性疾病中发挥着积极的作用，包括多发性硬化症（MS）。这些结构已经被研究过，因为它们与 MS 的诊断、疾病发展、治疗和预后过程有关。鉴于 MS 的进行性和神经退行性性质，miRNA 已被确定为该疾病的关键介质和分子靶点，这使它们成为获得合适生物标志物和治疗靶点的优秀候选者。本综述总结了 miRNA 在多发性硬化症中的作用的最新发现，包括它们在 MS 病因学和疾病的分子机制中的作用、将 miRNA 作为诊断工具和生物标志物的利用、miRNA 作为 MS 的治疗选择或靶点，以及它们作为疾病预后预测因子的意义。
