Conway Institute, UCD School of Medicine, University College Dublin, Belfield, Dublin, Ireland; Department of General Medicine, St. Vincent University Hospital, Elm Park, Dublin, Ireland.
Conway Institute, UCD School of Medicine, University College Dublin, Belfield, Dublin, Ireland.
Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188518. doi: 10.1016/j.bbcan.2021.188518. Epub 2021 Feb 3.
Triple Negative Breast Cancer (TNBC) is an aggressive tumour with patients survival rarely exceeding five years. TNBC tumours are larger in size, more chemoresistant, highly proliferative and usually more enriched in stem and immune cells comparing to other breast cancer subtypes. Functionally, these changes are dependent on a high-quality mitochondrial pool. Mitochondrial health is constantly assessed and appropriately improved by mitochondrial dynamics (cycles of mitochondrial fusion and division). Recent advances in understanding of mitochondrial dynamics in TNBC has demonstrated its critical importance in tumour growth and metastasis. This review explores current knowledge of mitochondrial dynamics in TNBC and discusses targeting this pathway clinically to improve outcomes for patients.
三阴性乳腺癌（TNBC）是一种侵袭性肿瘤，患者的生存时间很少超过五年。与其他乳腺癌亚型相比，TNBC 肿瘤体积更大、化疗耐药性更强、增殖活性更高，并且通常富含更多的干细胞和免疫细胞。从功能上讲，这些变化依赖于高质量的线粒体池。线粒体的健康状况通过线粒体动力学（线粒体融合和分裂的循环）不断进行评估和适当改善。目前对 TNBC 中线粒体动力学的理解的最新进展表明，其在肿瘤生长和转移中具有至关重要的作用。本综述探讨了 TNBC 中线粒体动力学的现有知识，并讨论了临床上靶向该途径以改善患者预后的问题。
