Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
The 4th Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 311053, China.
Pharmacol Res. 2021 Apr;166:105459. doi: 10.1016/j.phrs.2021.105459. Epub 2021 Feb 2.
Schisandrin B (Sch B) is the major active constituent of the traditional Chinese medicine Schisandra chinensis and has anti-inflammatory activity, but the target of Sch B remains unclear. T helper 17 (T17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases. Here, we showed that Sch B could decrease IL-17A production of CD4 T cells by targeting STAT3 in vitro. Importantly, Sch B has therapeutic effects on DSS-induced acute and chronic colitis, CD4CD45RB T cell-induced colitis. Furthermore, we identified T17 cells as the direct target of Sch B for mediating its anti-inflammatory activity. Sch B could serve as a lead for developing new therapeutics against T17 cells or IL-17A cytokine-driven diseases.
五味子丙素（Sch B）是中药五味子的主要活性成分，具有抗炎活性，但 Sch B 的靶点尚不清楚。辅助性 T 细胞 17（T17）细胞参与了许多自身免疫和炎症性疾病的发病机制。在这里，我们表明 Sch B 可以通过靶向 STAT3 在体外减少 CD4 T 细胞产生 IL-17A。重要的是，Sch B 对 DSS 诱导的急性和慢性结肠炎、CD4CD45RB T 细胞诱导的结肠炎具有治疗作用。此外，我们确定 T17 细胞是 Sch B 介导其抗炎活性的直接靶标。Sch B 可以作为开发针对 T17 细胞或 IL-17A 细胞因子驱动疾病的新型治疗药物的先导化合物。
