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五味子乙素通过抑制肝星状细胞活化和促进细胞凋亡减轻肝纤维化。

Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis.

机构信息

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.

出版信息

Molecules. 2021 Nov 15;26(22):6882. doi: 10.3390/molecules26226882.

DOI:10.3390/molecules26226882
PMID:34833975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8620732/
Abstract

The activation of hepatic stellate cells (HSC) plays a key role in the progression of hepatic fibrosis, it is essential to remove activated HSC through apoptosis to reverse hepatic fibrosis. Schisandrin B (Sch B) is the main chemical component of schisandrin lignan, and it has been reported to have good hepatoprotective effects. However, Schisandrin B on HSC apoptosis remains unclear. In our study, we stimulated the HSC-T6 and LX-2 cell lines with TGF-β1 to induce cell activation, and the proliferation and apoptosis of the activated HSC-T6 and LX-2 cells were detected after treatment with different doses of Schisandrin B. Flow cytometry results showed that Sch B significantly reduced the activity of activated HSC-T6 and LX-2 cells and significantly induced apoptosis. In addition, the cleaved-Caspase-3 levels were increased, the Bax activity was increased, and the Bcl-2 expression was decreased in HSC-T6 and LX-2 cells treated with Sch B. Our study showed that Sch B inhibited the TGF-β1-induced activity of hepatic stellate cells by promoting apoptosis.

摘要

肝星状细胞 (HSC) 的激活在肝纤维化的进展中起着关键作用，通过凋亡去除活化的 HSC 以逆转肝纤维化至关重要。五味子素 B (Sch B) 是五味子木脂素的主要化学成分，据报道具有良好的保肝作用。然而，Schisandrin B 对 HSC 凋亡的影响尚不清楚。在我们的研究中，我们用 TGF-β1 刺激 HSC-T6 和 LX-2 细胞系诱导细胞激活，并用不同剂量的五味子素 B 处理后检测活化的 HSC-T6 和 LX-2 细胞的增殖和凋亡。流式细胞术结果表明，Sch B 显著降低了活化的 HSC-T6 和 LX-2 细胞的活性，并显著诱导了细胞凋亡。此外，Sch B 处理的 HSC-T6 和 LX-2 细胞中 cleaved-Caspase-3 水平升高，Bax 活性增加，Bcl-2 表达减少。我们的研究表明，Sch B 通过促进细胞凋亡抑制 TGF-β1 诱导的肝星状细胞活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/3f44a92d9493/molecules-26-06882-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/30ac885684dc/molecules-26-06882-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/5953dfea767a/molecules-26-06882-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/1317861b2720/molecules-26-06882-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/79fbb3674d03/molecules-26-06882-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/3f44a92d9493/molecules-26-06882-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/30ac885684dc/molecules-26-06882-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/5953dfea767a/molecules-26-06882-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/1317861b2720/molecules-26-06882-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/79fbb3674d03/molecules-26-06882-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd92/8620732/3f44a92d9493/molecules-26-06882-g005.jpg

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