Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, 208016, U.P., India.
Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, 208016, U.P., India; Mehta Family Center for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, 208016, India.
Semin Cancer Biol. 2022 Aug;83:136-151. doi: 10.1016/j.semcancer.2021.01.009. Epub 2021 Feb 2.
Conrad Waddington's theory of epigenetic landscape epitomize the process of cell fate and cellular decision-making during development. Wherein the epigenetic code maintains patterns of gene expression in pluripotent and differentiated cellular states during embryonic development and differentiation. Over the years disruption or reprogramming of the epigenetic landscape has been extensively studied in the course of cancer progression. Cellular dedifferentiation being a key hallmark of cancer allow us to take cues from the biological processes involving epigenetic reprogramming in development such as the cellular differentiation and morphogenesis. Here, we discuss the role of epigenetic landscape and its modifiers in cell-fate determination, differentiation and prostate cancer progression. Lately, the emergence of RNA-modifications has also furthered our understanding of epigenetics in cancer. The overview of the epigenetic code regulating androgen signalling, and progression to aggressive neuroendocrine stage of PCa reinforces its gene regulatory functions during the development of prostate gland as well as cancer progression. Additionally, we also highlight the clinical implications of cancer cell epigenome, and discuss the recent advancements in the therapeutic strategies targeting the advanced stage disease.
康拉德·沃丁顿（Conrad Waddington）的表观遗传景观理论是胚胎发育过程中细胞命运和细胞决策的过程。在胚胎发育和分化过程中，表观遗传密码维持多能性和分化细胞状态下的基因表达模式。多年来，在癌症进展过程中，对表观遗传景观的破坏或重编程进行了广泛的研究。细胞去分化是癌症的一个关键标志，这使我们能够从涉及发育过程中表观遗传重编程的生物学过程中得到启示，如细胞分化和形态发生。在这里，我们讨论了表观遗传景观及其修饰物在细胞命运决定、分化和前列腺癌进展中的作用。最近，RNA 修饰的出现也进一步加深了我们对癌症中表观遗传学的理解。调节雄激素信号的表观遗传密码概述，以及向前列腺癌侵袭性神经内分泌阶段的进展，加强了其在前列腺发育以及癌症进展过程中的基因调控功能。此外，我们还强调了癌细胞表观基因组的临床意义，并讨论了针对晚期疾病的治疗策略的最新进展。
