Department of Interdisciplinary Medicine, University of Bari "Aldo Moro," Bari, Italy.
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro," Bari, Italy.
Cell Mol Gastroenterol Hepatol. 2021;11(5):1519-1539. doi: 10.1016/j.jcmgh.2021.01.012. Epub 2021 Feb 2.
Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage, and fibrosis. A genetic predisposition and environmental insults (ie, dietary habits, obesity) are putatively responsible for NASH progression. Here, we present the impact of the lipid-sensing nuclear receptors in the pathogenesis and treatment of NASH. In detail, we discuss the pros and cons of the putative transcriptional action of the fatty acid sensors (peroxisome proliferator-activated receptors), the bile acid sensor (farnesoid X receptor), and the oxysterol sensor (liver X receptors) in the pathogenesis and bona fide treatment of NASH.
非酒精性脂肪性肝病（NAFLD）是一种广泛的肝脏损伤，从单纯性脂肪变性到脂肪性肝炎和肝硬化。当肝脏脂肪变性伴有炎症、肝细胞损伤和纤维化时，即可诊断为非酒精性脂肪性肝炎（NASH）。遗传易感性和环境损伤（例如饮食习惯、肥胖）被认为是 NASH 进展的原因。在这里，我们介绍了脂质感知核受体在 NASH 的发病机制和治疗中的作用。具体来说，我们讨论了脂肪酸传感器（过氧化物酶体增殖物激活受体）、胆汁酸传感器（法尼醇 X 受体）和氧化固醇传感器（肝 X 受体）在 NASH 发病机制和真正治疗中的潜在转录作用的优缺点。
