Tran Melanie, Liu Yanjun, Huang Wendong, Wang Li
Department of Physiology and Neurobiology and Institute for Systems Genomics, University of Connecticut, Storrs, CT.
Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute City of Hope National Medical Center Duarte CA.
Hepatol Commun. 2018 Jun 14;2(7):765-777. doi: 10.1002/hep4.1203. eCollection 2018 Jul.
The nuclear receptor superfamily contains important transcriptional regulators that play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. Many nuclear receptors are ligand-activated transcription factors that regulate the expression of their target genes by modulating transcriptional activities and epigenetic changes. Additionally, the protein complex associated with nuclear receptors consists of a multitude of coregulators, corepressors, and noncoding RNAs. Therefore, acquiring new information on nuclear receptors may provide invaluable insight into novel therapies and shed light on new interventions to reduce the burden and incidence of liver diseases. ( 2018;2:765-777).
核受体超家族包含重要的转录调节因子，这些因子在细胞分化、发育、增殖和代谢过程中发挥多效性作用，以调控肝脏的生理和病理过程。许多核受体是配体激活的转录因子，它们通过调节转录活性和表观遗传变化来调控其靶基因的表达。此外，与核受体相关的蛋白质复合物由多种共调节因子、共抑制因子和非编码RNA组成。因此，获取有关核受体的新信息可能为新型疗法提供宝贵的见解，并为减轻肝脏疾病负担和降低其发病率的新干预措施提供线索。（2018年；2：765 - 777）
