自我报告的维生素 D 补充剂的使用与多发性硬化症患者更高的身体生活质量评分相关。

Self-reported use of vitamin D supplements is associated with higher physical quality of life scores in multiple sclerosis.

机构信息

Neuroepidemiology Unit, Melbourne School of Population & Global Health, The University of Melbourne, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Neuroepidemiology Unit, Melbourne School of Population & Global Health, The University of Melbourne, Melbourne, Australia; Sir Charles Gairdner Hospital, Nedlands, Australia.

出版信息

Mult Scler Relat Disord. 2021 Apr;49:102760. doi: 10.1016/j.msard.2021.102760. Epub 2021 Jan 16.

DOI:10.1016/j.msard.2021.102760

PMID:33545666

Abstract

BACKGROUND

Sun exposure and vitamin D, including intake and serum levels, have been associated with reduced risk of MS onset and less progression and may affect quality of life (QoL). We investigated the prospective relationship of these factors with QoL from baseline to 2.5 years' follow-up, in an international cohort of people with MS.

METHODS

Data derive from the HOLISM international cohort. Sun exposure and vitamin D supplement use were queried at both timepoints. QoL was assessed by MSQOL-54, estimating physical and mental health QoL composite scores. Characteristics of QoL were assessed by linear regression, adjusted for age, sex, socioeconomic status, treated comorbidity number, MS type, disability, clinically significant fatigue, prescription antidepressant medication use, and ongoing relapse symptoms, and baseline QoL score, as appropriate, estimating adjusted coefficients (aβ).

RESULTS

At 2.5-year review, QoL scores were higher among those reporting taking vitamin D supplements (physical: aβ=3.58, 95%CI=1.35-5.80; mental: aβ=3.08, 95%CI=0.72-5.44), particularly average daily dose over 5,000IU/d. Baseline-reported vitamin D supplementation was associated with greater increase in physical (aβ=1.02, 95%CI=0.22-1.81), but not mental QoL (aβ=0.11, 95%CI=-1.00-1.23). Sun exposure was cross-sectionally associated with higher QoL scores at follow-up but was not associated with change in QoL.

CONCLUSIONS

Self-reported vitamin D supplement use was cross-sectionally associated with higher physical and mental QoL, but prospectively only with increased physical QoL.

摘要

背景

阳光暴露和维生素 D，包括摄入和血清水平，与 MS 发病风险降低、进展减缓有关，可能影响生活质量（QoL）。我们在一项国际 MS 患者队列中，调查了这些因素与从基线到 2.5 年随访期间 QoL 的前瞻性关系。

方法

数据来自 HOLISM 国际队列。在两个时间点都询问了阳光暴露和维生素 D 补充剂的使用情况。使用 MSQOL-54 评估 QoL，估计身体和心理健康 QoL 综合评分。通过线性回归评估 QoL 的特征，调整了年龄、性别、社会经济地位、治疗合并症数量、MS 类型、残疾、临床显著疲劳、处方抗抑郁药物使用以及正在进行的复发症状，并根据需要调整了基线 QoL 评分，估计调整后的系数（aβ）。

结果

在 2.5 年的复查中，报告服用维生素 D 补充剂的患者 QoL 评分较高（身体：aβ=3.58，95%CI=1.35-5.80；精神：aβ=3.08，95%CI=0.72-5.44），特别是平均每天服用 5000IU/d 以上的剂量。基线报告的维生素 D 补充与身体 QoL 的更大增加相关（aβ=1.02，95%CI=0.22-1.81），但与精神 QoL 无关（aβ=0.11，95%CI=-1.00-1.23）。阳光暴露与随访时更高的 QoL 评分呈横断面相关，但与 QoL 的变化无关。