Nag Nupur, Yu Maggie, Jelinek George A, Simpson-Yap Steve, Neate Sandra L, Schmidt Hollie K
Neuroepidemiology Unit, Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC 3010, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, Australia.
J Pers Med. 2021 Nov 17;11(11):1218. doi: 10.3390/jpm11111218.
Multiple sclerosis (MS), a neuroinflammatory disorder, occurs as non-progressive or progressive phenotypes; both forms present with diverse symptoms that may reduce quality of life (QoL). Adherence to healthy lifestyle behaviors has been associated with higher QoL in people with MS; whether these associations differ based on MS phenotype is unknown. Cross-sectional self-reported observational data from 1108 iConquerMS participants were analysed. Associations between lifestyle behaviors and QoL were assessed by linear regression, and phenotype differences via moderation analyses. Diet, wellness, and physical activity, but not vitamin D or omega-3 supplement use, were associated with QoL. Specifically, certain diet types were negatively associated with QoL in relapsing-remitting MS (RRMS), and positively associated in progressive MS (ProgMS). Participation in wellness activities had mixed associations with QoL in RRMS but was not associated in ProgMS. Physical activity was positively associated with QoL in RRMS and ProgMS. Phenotype differences were observed in diet and wellness with physical QoL, and physical activity with most QoL subdomains. Our findings show lifestyle behaviors are associated with QoL and appear to differ based on MS phenotype. Future studies assessing timing, duration, and adherence of adopting lifestyle behaviors may better inform their role in MS management.
多发性硬化症（MS）是一种神经炎症性疾病，有非进展型或进展型两种表型；两种形式都表现出多种可能降低生活质量（QoL）的症状。坚持健康的生活方式行为与MS患者较高的生活质量相关；这些关联是否因MS表型而异尚不清楚。对来自1108名iConquerMS参与者的横断面自我报告观察数据进行了分析。通过线性回归评估生活方式行为与生活质量之间的关联，并通过调节分析评估表型差异。饮食、健康和体育活动与生活质量相关，但维生素D或ω-3补充剂的使用与生活质量无关。具体而言，某些饮食类型与复发缓解型MS（RRMS）的生活质量呈负相关，而与进展型MS（ProgMS）呈正相关。参与健康活动与RRMS的生活质量有混合关联，但与ProgMS无关。体育活动与RRMS和ProgMS的生活质量呈正相关。在饮食和健康方面观察到表型差异与身体生活质量有关，而体育活动与大多数生活质量子领域有关。我们的研究结果表明，生活方式行为与生活质量相关，并且似乎因MS表型而异。未来评估采用生活方式行为的时间、持续时间和依从性的研究可能会更好地说明它们在MS管理中的作用。
