用于增殖性玻璃体视网膜病变的水蛭：一项系统评价与荟萃分析方案
Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis.
作者信息
Huang Hui, Lei Ruxue, Li Yuanyuan, Huang Qun, Gao Na, Zou Weiwen
机构信息
Hospital of Chengdu University of Traditional Chinese Medicine.
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan.
出版信息
Medicine (Baltimore). 2021 Jan 22;100(3):e24412. doi: 10.1097/MD.0000000000024412.
INTRODUCTION
Proliferative vitreous retinopathy (PVR) is characterized by proliferation of cells and contraction of membranes on either the retinal surface or in the vitreous cavity, which leads to retinal detachment and visual impairment. PVR is commonly seen in patients with rhegmatogenous retinal detachment and diabetic retinopathy, which seriously affects the patient's work and life. Previous studies indicated that Hirudo (Leech) or compound prescription containing Hirudo (Leech) for treatment of PVR would be effective. However, due to the lack of evidence, there are no specific methods or suggestions, so it is necessary to carry out systematic evaluations on Hirudo (Leech) for PVR and provide effective evidence for further research.
METHODS AND ANALYSIS
The following 8 databases will be searched: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database, and Wanfang Database. All randomized controlled trials in English or Chinese related to Hirudo (Leech) for PVR will be included. Outcomes will include change in Vitreous opacity, Vision changes, production of the anterior macular membrane, and retinal detachment again. The incidence of adverse events will be assessed for safety evaluation. Study inclusion, data extraction and quality assessment will be performed independently by 2 reviewers. Assessment of risk of bias and data synthesis will be performed using Review Manager V.5.3.
RESULTS
In this systematic review and meta-analysis, we will synthesize the studies to assess the safety and efficacy of Hirudo (Leech) for PVR.
CONCLUSION
The summary of our study will clarify whether Hirudo (Leech) therapy could be an efficient and safe method for PVR, which can further guide the promotion and application of it.
OPEN SCIENCE FRAMEWORK OSF REGISTRATION NUMBER
10.17605/OSF.IO/FP7VG (https://osf.io/fp7vg).
引言
增殖性玻璃体视网膜病变（PVR）的特征是视网膜表面或玻璃体腔内细胞增殖和膜收缩，导致视网膜脱离和视力损害。PVR常见于孔源性视网膜脱离和糖尿病性视网膜病变患者，严重影响患者的工作和生活。先前的研究表明，水蛭或含水蛭的复方制剂治疗PVR可能有效。然而，由于缺乏证据，尚无具体方法或建议，因此有必要对水蛭治疗PVR进行系统评价，为进一步研究提供有效证据。
方法与分析
将检索以下8个数据库：Cochrane对照试验中心注册库、PubMed、MEDLINE、EMBASE、中国知网、中国生物医学文献数据库、维普数据库和万方数据库。纳入所有与水蛭治疗PVR相关的英文或中文随机对照试验。结局指标将包括玻璃体混浊的变化、视力变化、黄斑前膜的产生以及视网膜再次脱离。将评估不良事件的发生率以进行安全性评价。研究纳入、数据提取和质量评估将由2名研究者独立进行。将使用Review Manager V.5.3进行偏倚风险评估和数据合成。
结果
在本系统评价和荟萃分析中，我们将综合各项研究以评估水蛭治疗PVR的安全性和有效性。
结论
我们研究的总结将阐明水蛭疗法是否可能是一种治疗PVR的有效且安全的方法，这可以进一步指导其推广和应用。
开放科学框架（OSF）注册号：10.17605/OSF.IO/FP7VG（https://osf.io/fp7vg）
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