Du Wa, Ren Lu, Hamblin Milton H, Fan Yanbo
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Biomedicines. 2021 Feb 3;9(2):147. doi: 10.3390/biomedicines9020147.
Angiogenesis, a process of new blood vessel formation from the pre-existing vascular bed, is a critical event in various physiological and pathological settings. Over the last few years, the role of endothelial cell (EC) metabolism in angiogenesis has received considerable attention. Accumulating studies suggest that ECs rely on aerobic glycolysis, rather than the oxidative phosphorylation pathway, to produce ATP during angiogenesis. To date, numerous critical regulators of glucose metabolism, fatty acid oxidation, and glutamine metabolism have been identified to modulate the EC angiogenic switch and pathological angiogenesis. The unique glycolytic feature of ECs is critical for cell proliferation, migration, and responses to environmental changes. In this review, we provide an overview of recent EC glucose metabolism studies, particularly glycolysis, in quiescent and angiogenic ECs. We also summarize and discuss potential therapeutic strategies that take advantage of EC metabolism. The elucidation of metabolic regulation and the precise underlying mechanisms could facilitate drug development targeting EC metabolism to treat angiogenesis-related diseases.
血管生成是一个从预先存在的血管床形成新血管的过程，是各种生理和病理环境中的关键事件。在过去几年中，内皮细胞（EC）代谢在血管生成中的作用受到了相当多的关注。越来越多的研究表明，在血管生成过程中，内皮细胞依靠有氧糖酵解而非氧化磷酸化途径来产生ATP。迄今为止，已经确定了许多葡萄糖代谢、脂肪酸氧化和谷氨酰胺代谢的关键调节因子，以调节内皮细胞的血管生成开关和病理性血管生成。内皮细胞独特的糖酵解特性对于细胞增殖、迁移以及对环境变化的反应至关重要。在这篇综述中，我们概述了最近关于静息和血管生成内皮细胞中内皮细胞葡萄糖代谢的研究，特别是糖酵解。我们还总结并讨论了利用内皮细胞代谢的潜在治疗策略。对代谢调节及其精确的潜在机制的阐明有助于开发针对内皮细胞代谢的药物，以治疗与血管生成相关的疾病。
