Alfitni Daniyah, Ageel Maysaa, Alsulami Ebtesam, Alzahrani Abdullah
Department of Family Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, SAU.
Department of Clinical Sciences, Fakeeh College of Medical Sciences, Jeddah, SAU.
Cureus. 2024 Dec 14;16(12):e75691. doi: 10.7759/cureus.75691. eCollection 2024 Dec.
Objectives This study analyzed the practices and findings on postpartum type 2 diabetes mellitus (T2DM) screening among pregnant women with gestational diabetes mellitus (GDM). Methods A retrospective cohort study was conducted at a tertiary care center in Western Saudi Arabia, between January 1, 2016, and December 31, 2018. It involved 642 nondiabetic women with a confirmed diagnosis of GDM, who were followed until delivery. Sociodemographic and baseline clinical data, as well as data on GDM and postpartum diabetes screening, were collected from the hospital's electronic records. The incidence of T2DM following GDM was calculated as the percentage of screened participants with a positive postpartum diagnosis, along with 95% CI. Factors associated with T2DM were analyzed using Chi-square or Fisher's exact tests, with significance set at p<0.05. Results The sample consisted of 642 women, primarily young and of Saudi nationality, with a notable high-risk profile including prevalent overweight and obesity (87.7%), multiparity (42.7% having four parities or more), and a frequent family history of diabetes (33.3%). Screening practices showed a great disparity between the proportion of women ordered for screening (466, 72.5%) and those effectively screened (130, 20.2%). Women who had cesarean sections were more likely to take the screening (25.0%) compared with those who had spontaneous vaginal delivery (SVD) (16.5%) (p=0.023). The incidence of post-GDM T2DM among screened participants was estimated at 13.9% (18 among 130). The incidence of post-GDM T2DM increased significantly among women with a history of three or more GDM pregnancies (50% vs. <12.5%; p=0.033) compared to their counterparts, respectively. Post-GDM T2DM was also associated with SVD (20.6% vs. 7.6%) compared to cesarean section, respectively (p=0.042). No further demographic or clinical factors were shown to be significantly associated with screening or postpartum diabetes. Conclusions There is a substantial gap in screening, combined with a high incidence of postpartum diabetes, among women with GDM attending our center. This highlights the urgent need for improved screening efforts, utilizing a risk-stratified approach to facilitate early detection and intervention, which could enhance long-term health outcomes.
目的 本研究分析了妊娠糖尿病(GDM)孕妇产后2型糖尿病(T2DM)筛查的实践情况及结果。方法 于2016年1月1日至2018年12月31日在沙特阿拉伯西部的一家三级医疗中心进行了一项回顾性队列研究。研究纳入了642例确诊为GDM的非糖尿病孕妇,对其进行随访直至分娩。从医院电子记录中收集社会人口学和基线临床数据,以及GDM和产后糖尿病筛查的数据。GDM后T2DM的发病率以产后诊断阳性的筛查参与者的百分比计算,并计算95%可信区间。使用卡方检验或Fisher精确检验分析与T2DM相关的因素,显著性设定为p<0.05。结果 样本包括642名女性,主要为年轻的沙特国籍女性,具有显著的高危特征,包括普遍超重和肥胖(87.7%)、多产(42.7%有四次或更多次分娩)以及家族糖尿病史频繁(33.3%)。筛查实践显示,接受筛查医嘱的女性比例(466例,72.5%)与实际接受有效筛查的女性比例(130例,20.2%)之间存在很大差异。与自然阴道分娩(SVD)的女性相比,剖宫产的女性更有可能接受筛查(25.0%)(16.5%)(p=0.023)。在接受筛查的参与者中,GDM后T2DM的发病率估计为13.9%(130例中有18例)。与有三次或更多次GDM妊娠史的女性相比,其GDM后T2DM的发病率显著增加(50%对<12.5%;p=0.033)。与剖宫产相比,GDM后T2DM也与SVD相关(20.6%对7.6%)(p=0.042)。未发现进一步的人口统计学或临床因素与筛查或产后糖尿病有显著关联。结论 在我们中心就诊的GDM女性中,筛查存在很大差距,同时产后糖尿病发病率较高。这突出表明迫切需要改进筛查工作,采用风险分层方法以促进早期发现和干预,从而改善长期健康结局。