Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium
Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium.
Br J Ophthalmol. 2022 Jun;106(6):760-764. doi: 10.1136/bjophthalmol-2018-312337. Epub 2021 Feb 5.
BACKGROUND/OBJECTIVE: Anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) are two non-invasive imaging techniques used for the measurement of tumour thickness in corneal and bulbar conjunctival tumours. Histopathology (HP), however, remains the gold standard for the measurement of tumour thickness. The aim of this study was to determine whether AS-OCT and UBM are as accurate as HP for measuring tumour thickness.
Forty-two corneal and bulbar conjunctival tumours were imaged using AS-OCT and UBM. Images were assessed and tumour thickness was measured. Eleven patients subsequently underwent surgical excision. All specimens were measured during histopathological analysis. The correlation of the thickness measurement on HP to AS-OCT and UBM was then statistically analysed. In cases where the tumour was not excised, thickness measurement comparisons between AS-OCT and UBM were analysed.
AS-OCT and UBM measurements of tumour thickness were found to be significantly positively correlated (p=<0.001), as were UBM and HP thickness measurements (p=0.031). HP and AS-OCT measurements, however, only showed a mild but non-significant positive correlation.
Both AS-OCT and UBM are useful techniques to image and measure the thickness of corneal and conjunctival bulbar tumours. While AS-OCT provides better details than UBM, it was more limited in visualising the posterior boundary of the tumour, particularly in malignant tumours. While thickness measurements of both methodologies were correlated, neither should yet be considered as replacements to the gold standard of HP.
背景/目的：眼前节光学相干断层扫描（AS-OCT）和超声生物显微镜（UBM）是两种用于测量角膜和球结膜肿瘤厚度的非侵入性成像技术。然而，组织病理学（HP）仍然是测量肿瘤厚度的金标准。本研究旨在确定 AS-OCT 和 UBM 在测量肿瘤厚度方面是否与 HP 一样准确。
使用 AS-OCT 和 UBM 对 42 例角膜和球结膜肿瘤进行成像。评估图像并测量肿瘤厚度。随后，有 11 名患者接受了手术切除。所有标本均在组织病理学分析过程中进行测量。然后对 HP 与 AS-OCT 和 UBM 的厚度测量相关性进行统计学分析。在未切除肿瘤的情况下，分析了 AS-OCT 和 UBM 之间的厚度测量比较。
发现 AS-OCT 和 UBM 测量的肿瘤厚度呈显著正相关（p<0.001），UBM 和 HP 厚度测量也是如此（p=0.031）。然而，HP 和 AS-OCT 测量值仅显示出轻度但无统计学意义的正相关。
AS-OCT 和 UBM 都是用于成像和测量角膜和球结膜肿瘤厚度的有用技术。虽然 AS-OCT 提供的细节比 UBM 更好，但它在观察肿瘤的后边界方面受到限制，尤其是在恶性肿瘤中。虽然两种方法的厚度测量值都相关，但目前都不能被视为 HP 金标准的替代品。
