Yu Lio, Oh Chad, Shea Christopher R
Radiation Oncology, Laserderm Dermatology, Smithtown, NY, USA.
SkinCure Oncology, Burr Ridge, Illinois, USA.
Oncol Ther. 2021 Jun;9(1):153-166. doi: 10.1007/s40487-021-00138-4. Epub 2021 Feb 5.
An image-guided form of superficial ionizing radiation therapy (IGSRT) is becoming a commonly used alternative to surgery for non-melanoma skin cancer (NMSC). However, there is little literature evidence evaluating the efficacy and safety of this approach. This study evaluates the efficacy and safety of IGSRT in treating a large number of patients with NMSC.
The medical records of 1632 stage 0-II patients with 2917 invasive and in situ NMSC lesions treated from years 2017 to 2020 were reviewed. No patients had clinical evidence of regional lymph node or distant disease at presentation.
Treatment, guided by pre-treatment ultrasound imaging to adjust radiation energy and dose, combined with a fractionation treatment schedule of 20 or more treatment fractions, was safe and well tolerated. Of 2917 NMSC lesions treated, local tumor control was achieved in 2897 lesions, representing a 99.3% rate of control.
IGSRT should be considered as a first-line option for treating NMSC tumors in suitable early stage patients. Cure rates observed in this initial period of follow-up are similar, and potentially superior with further follow-up, to traditional superficial radiation therapy (SRT) and surgical options.
图像引导的浅表电离辐射疗法（IGSRT）正成为非黑色素瘤皮肤癌（NMSC）手术的常用替代方法。然而，评估这种方法疗效和安全性的文献证据很少。本研究评估了IGSRT治疗大量NMSC患者的疗效和安全性。
回顾了2017年至2020年期间1632例0-II期患者的病历，这些患者有2917处侵袭性和原位NMSC病变。所有患者在就诊时均无区域淋巴结或远处疾病的临床证据。
在治疗前超声成像引导下调整辐射能量和剂量，并结合20次或更多次分割治疗方案，该治疗安全且耐受性良好。在治疗的2917处NMSC病变中，2897处病变实现了局部肿瘤控制，控制率为99.3%。
对于合适的早期患者，IGSRT应被视为治疗NMSC肿瘤的一线选择。在这一初始随访期观察到的治愈率与传统浅表放射治疗（SRT）和手术选择相似，且随着进一步随访可能更优。
