Faculty of Science, Department of Physics, Mansoura University, Mansoura, Egypt.
Department of Spectroscopy, Molecular Spectroscopy and Modeling Unit, National Research Center, Giza, Egypt.
Microsc Res Tech. 2021 Jul;84(7):1596-1606. doi: 10.1002/jemt.23720. Epub 2021 Feb 5.
Recently, scientific research has confirmed that a single polymer material cannot meet the ambitions of all surgical requirements. Thus, combinations of different types of polymeric materials are used in order to manufacture different suture materials. A copolymer of Polyglycolide (PGA) and trimethylene carbonate (TMC) is one of the simplest bioabsorbable monofilament sutures. The optical properties of PGA/TMC copolymer surgical suture were investigated by using multiple-beam interferometric of Fizeau type. The mechanical properties were measured by a suture-drawing apparatus attached to the multiple-beam interferometric system. The refractive indices, stress-strain curve, elastic shear modulus, Young's modulus and crosslink density were investigated for the PGA/TMC surgical suture at various draw ratios. The biological activities were conducted by Quantitative Structure Activity Relationships (QSAR) descriptors. Molecular Electrostatic Potential (MESP) maps were used to describe the reactivity and functional active sites for the given molecule. The behavior of stress-strain curve confirms the compatibility of the suture with the sternum which proves that this suture is a good candidate for cardiac operations. RESEARCH HIGHLIGHTS: Fizeau fringes is accurate in characterizing properties of PGA/TMC surgical suture. The biological activities were conducted by (QSAR) descriptors. The compatibility measurements lead to it is a good candidate for cardiac operations.
最近，科学研究已经证实，单一的聚合物材料无法满足所有手术需求。因此，为了制造不同类型的缝合材料，人们会将不同类型的聚合物材料组合在一起。聚乙醇酸（PGA）和三亚甲基碳酸酯（TMC）的共聚物是最简单的可生物吸收的单丝缝合线之一。使用 Fizeau 型多光束干涉仪研究了 PGA/TMC 共聚物手术缝合线的光学性质。通过连接到多光束干涉系统的缝合线拉伸装置测量了机械性能。研究了不同拉伸比下 PGA/TMC 手术缝合线的折射率、拉伸应变曲线、弹性剪切模量、杨氏模量和交联密度。通过定量构效关系（QSAR）描述符进行了生物活性研究。分子静电势（MESP）图用于描述给定分子的反应性和功能活性位点。拉伸应变曲线的行为证实了缝合线与胸骨的相容性，这证明了这种缝合线是心脏手术的良好候选材料。研究亮点：菲佐条纹能准确地描述 PGA/TMC 手术缝合线的性能。通过 QSAR 描述符进行生物活性研究。相容性测量表明，它是心脏手术的良好候选材料。
