Effects of allogenic acellular dermal matrix combined with autologous razor-thin graft on hand appearance and function of patients with extensive burn combined with deep hand burn.

The aim of the study was to observe the effect of allogeneic acellular dermal matrix (ADM) combined with autologous razor-thin graft on the appearance and function of hands in patients with extremely large area burns combined with deep hand burns. Sixty-four patients with severe burn combined with deep burn of the hand in our hospital from August 2015 to August 2019 were selected as the study subjects. All patients were randomly divided into the study group (32 cases, given allogeneic ADM combined with autologous razor-thin graft) and the control group (32 cases, given autologous scar tissue combined with autologous razor-thin graft). Hand appearance, wound healing, wound contraction, hand function, and quality of life were compared between the two groups at 3 and 6 months after treatment. The vascular distribution, skin thickness, and flexibility scores of the two groups 6 months post operation were lower than those of the 3 months post operation (P < .05). At 6 months after operation, there were significant differences in blood vessel distribution, skin thickness, flexibility, and colour between the two groups (P < .05). The wound healing rate and wound contraction rate of the two groups at 6 months after operation were higher than those at 3 months after operation (P < .05). The wound healing rate of the study group was higher than that of the control group (P < .05), but there was no significant difference in the wound contraction rate between the two groups. Hand function was better in both groups 6 months after operation than 3 months after operation (P < .05). The hand function of the experimental group was better than that of the control group at 3 and 6 months after operation (P < .05). The quality of life in the two groups at 6 months after operation was significantly higher than that at 3 months after operation, and the quality of life in the study group was consistently higher than that in the control group (P < .05). Allogeneic ADM combined with razor-thin graft in the treatment of patients with extensive burns and deep hand burns can effectively restore the shape and function of the hand, which is conducive to wound healing and improve the quality of life of patients, and it is worthy of wide clinical application.