Eye Hospital of Wenzhou Medical University at hanghzou, 618 Fengqi east Road, Hangzhou, 310000, Zhejiang, China.
Int Ophthalmol. 2021 May;41(5):1605-1612. doi: 10.1007/s10792-021-01694-4. Epub 2021 Feb 6.
To evaluate the early changes in retinal microcirculation after uncomplicated cataract surgery using an active-fluidics system.
Patients underwent uncomplicated cataract surgery for both eyes were enrolled. The two eyes of the patients were randomly assigned to two groups, the active-fluidics group and the gravity-fluidics group. One eye using an active-fluidics system, and the other using a gravity-fluidics system. Optical coherence tomography angiography (OCTA) was performed at 1 day, 7 days, 30 days, and 90 days after surgery.
Fifty eyes (25 patients) were included in the final analysis. A significantly lower cumulative dissipated energy (CDE), estimated fluid usage (EFU), and total aspiration time (TAT) were observed in the active-fluidics group (all P<0.05). The superficial vessel density at parafoveal region increased at 7 days and 30 days after cataract surgery in the eyes of both the active-fluidics and gravity-fluidics groups, with the fluctuation in eyes of the gravity-fluidics group more significant. The vessel density of deep capillary plexus remained stable during the follow-up period. Significant changes of retinal thickness in macular region (fovea, parafovea) were observed in eyes of the gravity-fluidics group through the comparison of corresponding values at different time points (p = 0.008, 0.005). No significant change in retinal thickness was observed in eyes of the active-fluidics.
Retinal microcirculation and thickness were disturbed after cataract surgery using the gravity-fluidics infusion system. The active-fluidics system not only improved the surgical efficacy but also protected the retinal vasculature during cataract surgery.
The study has been registered at www.clinicaltrials.gov with its clinical trial accession number of NCT0130500.
使用主动流系统评估单纯性白内障手术后视网膜微循环的早期变化。
纳入行单纯性白内障手术的患者。患者双眼随机分为主动流组和重力流组，一组眼采用主动流系统，另一组眼采用重力流系统。分别于术后 1 天、7 天、30 天和 90 天行光学相干断层扫描血管造影（OCTA）检查。
最终有 50 只眼（25 例患者）纳入研究。主动流组的累积耗散能量（CDE）、估计液体使用量（EFU）和总抽吸时间（TAT）均显著降低（均 P<0.05）。术后 7 天和 30 天，两组患者的黄斑区旁中心凹区浅层血管密度均增加，重力流组的波动更明显。深层毛细血管丛的血管密度在随访期间保持稳定。与不同时间点的相应值相比，重力流组的黄斑区（中心凹、旁中心凹）视网膜厚度发生了显著变化（p = 0.008，0.005）。主动流组的视网膜厚度无明显变化。
使用重力流灌注系统进行白内障手术后，视网膜微循环和厚度受到干扰。主动流系统不仅提高了手术效果，而且在白内障手术过程中保护了视网膜血管。
该研究已在 www.clinicaltrials.gov 上注册，其临床试验注册号为 NCT0130500。
