School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.
J Am Acad Dermatol. 2021 Dec;85(6):1493-1502. doi: 10.1016/j.jaad.2021.01.094. Epub 2021 Feb 3.
Tonsillectomy has been suggested as an intervention to resolve psoriasis.
This study aimed to investigate the subsequent risk of psoriasis in patients who received tonsillectomy.
We used data from the Taiwan National Health Insurance Research Database. The tonsillectomy group (case group) and the tonsillectomy-free group (comparison group) were matched at a ratio of 1:4 by demographic data, comorbidities, medical confounders, and the index date. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
We identified 2021 patients as the case group and matched 8084 individuals as the comparison group. The adjusted HR (aHR) of psoriasis was 0.43 (95% CI, 0.22-0.87; P < .05). The study population is composed of a mainly male (65%) and young population (mostly younger than 50 years). Notably, patients with rheumatoid arthritis increased the risk of psoriasis (aHR, 3.97; 95% CI, 1.17-13.48; P < .05). In our stratification analysis, the risk of psoriasis decreased in almost all subgroups.
Our database did not include information on genome and the subtypes of psoriasis.
Our study showed a decreased risk of psoriasis in the tonsillectomy group after adjustment for baseline characteristics, comorbidities, and medical confounders compared with the reference group.
扁桃体切除术被认为是一种可以解决银屑病的干预措施。
本研究旨在调查接受扁桃体切除术的患者随后发生银屑病的风险。
我们使用了来自台湾全民健康保险研究数据库的数据。扁桃体切除术组（病例组）和扁桃体切除术组（对照组）按照人口统计学数据、合并症、医学混杂因素和索引日期以 1:4 的比例进行匹配。使用 Cox 比例风险模型估计风险比（HR）和 95%置信区间（CI）。
我们确定了 2021 名患者为病例组，并匹配了 8084 名个体为对照组。银屑病的调整后 HR（aHR）为 0.43（95%CI，0.22-0.87；P<.05）。研究人群主要由男性（65%）和年轻人群（大多年龄小于 50 岁）组成。值得注意的是，类风湿关节炎患者增加了患银屑病的风险（aHR，3.97；95%CI，1.17-13.48；P<.05）。在我们的分层分析中，银屑病的风险几乎在所有亚组中均降低。
我们的数据库不包括基因组和银屑病亚型的信息。
与对照组相比，调整基线特征、合并症和医学混杂因素后，我们的研究显示扁桃体切除术组发生银屑病的风险降低。
