School of Medicine, Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Medical Research, Chung Shan Medical University, Hospital, Taichung, Taiwan.
Int J Epidemiol. 2020 Jun 1;49(3):786-797. doi: 10.1093/ije/dyaa027.
This study investigated whether patients with a history of human papillomavirus (HPV) infection are at increased risk of developing psoriasis.
We enrolled 66 274 patients with HPV infection between 1997 and 2013 from the Taiwan National Health Insurance Research Database, and compared them with control individuals who had never been diagnosed with HPV infection (at a 1:4 ratio matched by age, sex and index year) in relation to the risk of developing psoriasis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with the control group as reference.
The adjusted hazard ratio (aHR) was 1.177 (95% CI, 1.010-1.373) after adjusting for demographic characteristics, comorbidities, dermatology-related outpatient visits and medications. The HPV group had an increased risk of psoriasis compared with the control group in all of the different age groups. The P-value for interaction between age and exposure of HPV is 0.009 in our sub-group analysis.
A higher risk of psoriasis was found after HPV infection, and age acted as an effect modifier between the HPV infection and risk of psoriasis.
本研究旨在探讨 HPV 感染史是否会增加患者发生银屑病的风险。
我们从台湾全民健康保险研究数据库中招募了 1997 年至 2013 年间的 66274 例 HPV 感染患者，并将他们与从未被诊断为 HPV 感染的对照组个体（按年龄、性别和索引年进行 1:4 匹配）进行比较，以评估发生银屑病的风险。使用 Cox 比例风险模型估计风险比（HR）和 95%置信区间（CI），以对照组为参照。
在调整人口统计学特征、合并症、皮肤科相关门诊就诊和药物治疗后，调整后的 HR 为 1.177（95%CI，1.010-1.373）。与对照组相比，HPV 组在所有不同年龄组中均有更高的银屑病发病风险。我们的亚组分析中，年龄和 HPV 暴露之间的交互作用 P 值为 0.009。
HPV 感染后发生银屑病的风险增加，年龄是 HPV 感染与银屑病风险之间的效应修饰因素。
