Shimizu K, Hokano M
Department of Anatomy, Tokyo Medical College, Japan.
Anat Rec. 1988 Feb;220(2):138-42. doi: 10.1002/ar.1092200205.
The localization of collagenolytic activity within the tissue compartments of the mouse uterus was investigated during postpartum involution. The rate of collagenase activity was measured by analysis of tissue levels of hydroxyproline from the day of parturition to the 10th postpartum day. Collagen bonding was analyzed by viewing birefringence induced by the picrosirius red-binding technique. An attempt was made to interrelate quantitative analysis with the histologic distribution of collagen during postpartum days 1-10. Histologic and quantitative evidence indicated the following: 1) The collagenous compartments of the endometrium and myometrium differ in their response to the postpartum rise in collagenase activity; collagen degradation occurs primarily in the endometrium, that is, the myometrial collagen remains, but much of the endometrial collagen is removed. 2) Endometrial collagen is degraded particularly in the immediate subluminal compartment.
在产后子宫复旧过程中，对小鼠子宫组织各部分胶原酶活性的定位进行了研究。通过分析从分娩日到产后第10天组织中羟脯氨酸的水平来测定胶原酶活性的速率。采用天狼星红结合技术观察双折射来分析胶原结合情况。试图将产后第1 - 10天胶原的定量分析与组织学分布相互关联起来。组织学和定量证据表明：1）子宫内膜和子宫肌层的胶原部分对产后胶原酶活性升高的反应不同；胶原降解主要发生在子宫内膜，即子宫肌层的胶原保留下来，但大部分子宫内膜胶原被清除。2）子宫内膜胶原尤其在紧邻管腔的部分被降解。
