Kaidi R, Brown P J, David J S, Etherington D J, Robins S P
Department of Pathology, School of Veterinary Science, Langford, Bristol.
Matrix. 1991 Apr;11(2):101-7. doi: 10.1016/s0934-8832(11)80213-1.
Post-partum involution of the bovine uterus was assessed by clinical examination and monitored biochemically by measuring the total urinary excretion of hydroxyproline and the collagen cross-link, pyridinoline. Uterine tissue contained 0.13 +/- 0.04 residues of pyridinoline per mole of collagen and negligible (less than 0.005 residues/mole) deoxypyridinoline. The pyridinoline/creatinine ratio was found to be a clearer and more reliable indicator of uterine resorption than the hydroxyproline/creatinine ratio. The amount of collagen cross-link excreted above baseline was equivalent to the amount of cross-link estimated to have been accumulated during pregnancy. Maximal excretion of pyridinoline occurred at day 6 and returned to baseline values in 2-3 weeks after parturition. An electron microscope study during the period of peak resorption revealed macrophage-like cells apparently engulfing or containing collagenous material, indicating phagocytic removal of the connective tissue.
通过临床检查评估了牛子宫的产后复旧情况，并通过测量羟脯氨酸的总尿排泄量和胶原交联物吡啶啉进行生化监测。子宫组织中每摩尔胶原含有0.13±0.04个吡啶啉残基，脱氧吡啶啉含量可忽略不计（小于0.005个残基/摩尔）。发现吡啶啉/肌酐比值比羟脯氨酸/肌酐比值更清晰、更可靠地指示子宫吸收情况。高于基线排泄的胶原交联量相当于估计在怀孕期间积累的交联量。吡啶啉的最大排泄量出现在第6天，产后2 - 3周恢复到基线值。在吸收高峰期的电子显微镜研究显示，巨噬细胞样细胞明显吞噬或含有胶原物质，表明结缔组织被吞噬清除。
