西咪替丁不抑制血浆胆碱酯酶活性。
Cimetidine does not inhibit plasma cholinesterase activity.
作者信息
Cook D R, Stiller R L, Chakravorti S, Mannenhira T
机构信息
Department of Anesthesiology, Children's Hospital of Pittsburgh, Pennsylvania.
出版信息
Anesth Analg. 1988 Apr;67(4):375-6.
PMID:3354873
Abstract
Cimetidine increases the duration of action of succinylcholine several-fold by an unknown mechanism. The hydrolysis rate of succinylcholine by human plasma was measured with a modified spectrophotometric assay. At a concentration of 1-50 micrograms/ml cimetidine did not inhibit the hydrolysis of succinylcholine. It is concluded that cimetidine may have an effect at the neuromuscular junction but does not inhibit plasma cholinesterase.
摘要
西咪替丁通过一种未知机制将琥珀酰胆碱的作用持续时间延长了数倍。采用改良分光光度法测定了人血浆中琥珀酰胆碱的水解速率。在浓度为1 - 50微克/毫升时，西咪替丁并不抑制琥珀酰胆碱的水解。得出的结论是，西咪替丁可能在神经肌肉接头处产生作用，但并不抑制血浆胆碱酯酶。
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