缬草中具有抗炎和抗增殖活性的环烯醚萜类化合物。
Iridoids from Valeriana jatamansi with anti-inflammatory and antiproliferative properties.
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.
Laboratory of Animal Tumor Models, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China.
出版信息
Phytochemistry. 2021 Apr;184:112681. doi: 10.1016/j.phytochem.2021.112681. Epub 2021 Feb 4.
Seven undescribed (valejatadoids A-G) and 26 known iridoids were obtained from the roots and rhizomes of Valeriana jatamansi. Their structures were determined based on extensive spectroscopic data, especially 1D and 2D NMR, along with HRESIMS. Valejatadoid B is a monoene-type iridoid with a unique double bond between C-4 and C-5. Valejatadoids D-G, jatamanin U, jatamanin O, jatamanvaltrate E, valeriotetrate C, IVHD-valtrate, 10-isovaleroxy-valtrathydrin, jatamanvaltrate Q, valeriandoid F, jatamanvaltrate K, jatamanvaltrate W and isovaltrate were more potent than the positive control when evaluated for inhibition of NO production. Among them, valeriandoid F and jatamanvaltrate K exhibited the most significant inhibitory effects with IC values of 0.88 and 0.62 μM, respectively. In addition, valeriandoid F selectively inhibited the proliferation of human glioma stem cell lines, GSC-3# and GSC-18#, with IC values of 7.16 and 5.75 μM, respectively.
从缬草根和根茎中分离得到了 7 个未描述的（缬草萜 A-G）和 26 个已知的环烯醚萜。根据广泛的光谱数据，特别是 1D 和 2D NMR 以及 HRESIMS，确定了它们的结构。缬草萜 B 是一种单烯型环烯醚萜，具有 C-4 和 C-5 之间独特的双键。缬草萜 D-G、缬草萜 U、缬草萜 O、缬草苦酯 E、缬草酯 C、IVHD-缬草酯、10-异缬草酸缬草酯、缬草苦酯 Q、缬草二萜 F、缬草苦酯 K、缬草苦酯 W 和异缬草酸酯在抑制 NO 产生的活性评价中比阳性对照物更有效。其中，缬草二萜 F 和缬草苦酯 K 表现出最显著的抑制作用，IC 值分别为 0.88 和 0.62 μM。此外，缬草二萜 F 选择性地抑制了人神经胶质瘤干细胞系 GSC-3# 和 GSC-18#的增殖，IC 值分别为 7.16 和 5.75 μM。
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