Department of Orthopedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany; Center for Musculoskeletal Surgery Osnabrück (OZMC), Klinikum Osnabrück, Osnabrück, Germany.
Institute of Movement and Training Science I, University of Leipzig, Leipzig, Germany.
Ultrasound Med Biol. 2021 May;47(5):1269-1278. doi: 10.1016/j.ultrasmedbio.2021.01.003. Epub 2021 Feb 4.
The aim of this randomized controlled laboratory study was to evaluate the role of standardized protection, rest, ice (cryotherapy), compression and elevation (PRICE) therapy on microvascular blood flow in human skeletal muscle. Quantifiable contrast-enhanced ultrasound was used to analyze intramuscular tissue perfusion (ITP) of the rectus femoris (RF) and vastus intermedius (VI) muscles in 20 healthy athletes who were randomly assigned to PRICE or control groups. Baseline perfusion measurements (resting conditions, T) were compared with cycling exercise (T), intervention (PRICE or control, T) and follow-up at 60 min post-intervention (T). The 20 min PRICE intervention included rest, cryotherapy (3°C), compression (35 mm Hg) and elevation. After intervention, PRICE demonstrated a decrease of ITP in VI (-47%, p = 0.01) and RF (-50%, p = 0.037) muscles. At T an ongoing decreased ITP for the RF (p = 0.003) and no significant changes for the VI were observed. In contrast, the control group showed an increased ITP at T and no significant differences at T. PRICE applied after exercise led to a down-regulation of ITP, and the termination of PRICE does not appear to be associated with a reactive hyperemia for at least 60 min after treatment.
本随机对照实验室研究旨在评估标准化保护、休息、冰敷（冷冻疗法）、加压和抬高（PRICE）疗法对人体骨骼肌微血管血流的作用。使用可量化的对比增强超声分析 20 名健康运动员的股直肌（RF）和股中间肌（VI）的肌肉内组织灌注（ITP），这些运动员被随机分配到 PRICE 或对照组。与循环运动（T）、干预（PRICE 或对照，T）和 60 分钟后随访（T）相比，比较了基线灌注测量（休息条件，T）。20 分钟的 PRICE 干预包括休息、冰敷（3°C）、加压（35mmHg）和抬高。干预后，PRICE 显示 VI（-47%，p=0.01）和 RF（-50%，p=0.037）肌肉的 ITP 下降。在 T 时，RF 的 ITP 持续下降（p=0.003），VI 没有明显变化。相比之下，对照组在 T 时 ITP 增加，T 时没有显著差异。运动后应用 PRICE 导致 ITP 下调，PRICE 终止后至少 60 分钟内似乎没有与反应性充血相关。
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