Department of Infection Control Science, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan; Department of Infectious Disease Medicine, Osaka City University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan; Department of Respiratory Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan; Department of Infection Control and Prevention, Osaka City University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan.
Department of Surgery, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
J Infect Chemother. 2021 Jun;27(6):906-910. doi: 10.1016/j.jiac.2021.01.005. Epub 2021 Feb 3.
Corynebacterium jeikeium normally presents on human skin, and it is often judged as contamination when it is cultured from blood. C. jeikeium can cause infective endocarditis, especially, that associated with cardiac surgery and prosthetic valvular endocarditis.
A 66-year-old Japanese male patient was diagnosed with C. jeikeium-induced infective endocarditis (IE) and perivalvular abscess after a coronary artery bypass grafting and aortic valve replacement with bioprosthesis; pyogenic spondylodiscitis was also observed. Patch repair for aortic valve annulus and re-Bentall procedure with bioprosthesis was performed for IE and perivalvular abscess. The causative bacterium was confirmed as C. jeikeium on 16S ribosomal RNA sequencing of surgical sample and positive blood culture. The patient underwent six weeks of intravenous antibacterial treatment with vancomycin and an additional two weeks of oral treatment with linezolid, following which, his condition improved. Corynebacterium jeikeium can cause infective endocarditis and perivalvular abscess, which is a more severe condition than IE.
16S ribosomal RNA sequencing is useful in diagnosing bacterial species that can cause contamination, such as Corynebacterium spp.
棒状杆菌属通常存在于人体皮肤上，当其从血液中培养出来时，通常被判断为污染。棒状杆菌可引起感染性心内膜炎，尤其是与心脏手术和人工瓣膜心内膜炎相关的感染性心内膜炎。
一名 66 岁的日本男性患者在冠状动脉旁路移植术和主动脉瓣置换术后，被诊断为棒状杆菌引起的感染性心内膜炎（IE）和瓣周脓肿；还观察到化脓性脊椎炎。IE 和瓣周脓肿采用主动脉瓣环修补和生物瓣再 Bentall 手术进行治疗。手术样本的 16S 核糖体 RNA 测序和阳性血培养证实了病原体为棒状杆菌。患者接受了 6 周的万古霉素静脉抗菌治疗和 2 周的口服利奈唑胺治疗，病情得到改善。棒状杆菌可引起感染性心内膜炎和瓣周脓肿，比 IE 更为严重。
16S 核糖体 RNA 测序有助于诊断可引起污染的细菌种类，如棒状杆菌属。
