ARS Agenzia Regionale Sanità, Toscana Italy.
Diabetology, Careggi Hospital, Florence, Italy.
Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):769-773. doi: 10.1016/j.numecd.2020.11.030. Epub 2020 Dec 8.
Aim of the present study is to determine the role of obesity as a risk factor for COronaVirus Disease-19 (COVID-19) hospitalization.
This observational study was performed using Istituto Superiore di Sanità (ISS) Tuscany COVID-19 database by the Agenzia Regionale Sanità (ARS), including all COVID-19 cases registered until April 30th, 2020, with reported information on chronic diseases. The principal outcome was hospitalization. An age and gender-adjusted logistic regression model was used to assess the association of clinical and demographic characteristics with hospitalization. Further multivariate models were applied. Of 4481 included subjects (36.9% aged over 70 years), 1907 (42.6%) were admitted to hospital. Obesity was associated with hospitalization after adjusting for age and gender. The association of obesity with hospitalization retained statistical significance in a fully adjusted model, including possible confounders (OR: 2.99 [IC 95% 2.04-4.37]). The effect of obesity was more evident in younger (<70 years) than in older (≥70 years) subjects.
The present data confirm that obesity is associated with an increased risk of hospitalization in patients with COVID-19. Interestingly, the association of obesity with hospitalization was greater in younger (<70 years) patients.
本研究旨在确定肥胖是否为感染 COVID-19 住院的危险因素。
本观察性研究使用意大利卫生研究所（ISS）托斯卡纳 COVID-19 数据库，由区域卫生局（ARS）进行，包括截至 2020 年 4 月 30 日登记的所有 COVID-19 病例，报告了慢性疾病信息。主要结局是住院。使用年龄和性别调整的逻辑回归模型评估临床和人口统计学特征与住院的相关性。进一步应用多变量模型。在纳入的 4481 例患者中（36.9%年龄超过 70 岁），1907 例（42.6%）住院。在调整年龄和性别后，肥胖与住院相关。在包括可能混杂因素的完全调整模型中，肥胖与住院的相关性仍然具有统计学意义（OR：2.99 [95%CI 2.04-4.37]）。肥胖对住院的影响在年龄较小（<70 岁）的患者中比年龄较大（≥70 岁）的患者中更为明显。
本数据证实肥胖与 COVID-19 患者住院风险增加相关。有趣的是，肥胖与住院的相关性在年龄较小（<70 岁）的患者中更大。
