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Leptin as a potential prognostic marker of the severity of COVID-19 infection in obese patients.瘦素作为肥胖患者新冠病毒感染严重程度的潜在预后标志物。
Nutr Metab Cardiovasc Dis. 2022 Mar;32(3):743-744. doi: 10.1016/j.numecd.2021.12.003. Epub 2021 Dec 10.
2
Leptin Deficiency, Caused by Malnutrition, Makes You Susceptible to SARS-CoV-2 Infection but Could Offer Protection from Severe COVID-19.由营养不良引起的瘦素缺乏会使你易感染新冠病毒，但可能为严重的新冠肺炎提供保护。
mSphere. 2021 May 12;6(3):e00031-21. doi: 10.1128/mSphere.00031-21.
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Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link?肥胖症是 SARS-CoV-2 最常见的合并症：瘦素是其中的联系吗？
Int J Obes (Lond). 2020 Sep;44(9):1810-1817. doi: 10.1038/s41366-020-0640-5. Epub 2020 Jul 9.
4
COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality.肥胖与 COVID-19 严重程度：瘦素和炎症细胞因子在高发病率和死亡率之间关联中的相互作用。
Front Immunol. 2021 Jun 18;12:649359. doi: 10.3389/fimmu.2021.649359. eCollection 2021.
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Clinical, Immunological, and Virological SARS-CoV-2 Phenotypes in Obese and Nonobese Military Health System Beneficiaries.肥胖和非肥胖军人群体中 SARS-CoV-2 的临床、免疫学和病毒学表型。
J Infect Dis. 2021 Nov 16;224(9):1462-1472. doi: 10.1093/infdis/jiab396.
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Association between obesity and clinical prognosis in patients infected with SARS-CoV-2.肥胖与 SARS-CoV-2 感染患者临床预后的关系。
Infect Dis Poverty. 2020 Jun 29;9(1):80. doi: 10.1186/s40249-020-00703-5.
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COVID-19, Virchow's triad and thromboembolic risk in obese pregnant women.2019冠状病毒病、肥胖孕妇的魏尔啸三联征与血栓栓塞风险
Clin Cardiol. 2021 May;44(5):593-594. doi: 10.1002/clc.23602. Epub 2021 Mar 24.
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As a matter of fat: Leptin, monocyte hyperactivation, and COVID-19: A commentary to "Leptin correlates with monocytes activation and severe condition in COVID-19 patients".事实上：瘦素、单核细胞过度活化与2019冠状病毒病——对《瘦素与2019冠状病毒病患者单核细胞活化及重症相关》的述评
J Leukoc Biol. 2021 Jul;110(1):7-8. doi: 10.1002/JLB.3CE1220-799R. Epub 2021 Apr 13.
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Obesity and Risk of COVID-19 Infection and Severity: Available Evidence and Mechanisms.肥胖与 COVID-19 感染和严重程度的关系：现有证据和机制。
Adv Exp Med Biol. 2021;1321:97-107. doi: 10.1007/978-3-030-59261-5_8.
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Fatty liver disease in obese patients with COVID-19: a tale of two pandemics?新冠肺炎肥胖患者的脂肪肝疾病：两种大流行的故事？
Eur J Prev Cardiol. 2022 Feb 9;28(18):e49. doi: 10.1093/eurjpc/zwaa059.

引用本文的文献

1
Eosinophils and COVID-19: Insights into immune complexity and vaccine safety.嗜酸性粒细胞与新冠病毒病：对免疫复杂性和疫苗安全性的见解
Clin Transl Allergy. 2025 Mar;15(3):e70050. doi: 10.1002/clt2.70050.
2
Obesity-compromised immunity in post-COVID-19 condition: a critical control point of chronicity.肥胖损害新冠病毒感染后患者的免疫功能：慢性化的关键控制点。
Front Immunol. 2024 Aug 12;15:1433531. doi: 10.3389/fimmu.2024.1433531. eCollection 2024.
3
Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review.探讨 SARS-CoV-2 感染中脂肪细胞因子与炎症反应的网络关系：范围综述。
Nutrients. 2023 Aug 30;15(17):3806. doi: 10.3390/nu15173806.
4
Infections and immunity: associations with obesity and related metabolic disorders.感染与免疫：与肥胖及相关代谢紊乱的关联
J Pathol Transl Med. 2023 Jan;57(1):28-42. doi: 10.4132/jptm.2022.11.14. Epub 2023 Jan 15.

本文引用的文献

1
The association between BMI and metabolically unhealthy status with COVID-19 mortality: Based on 3019 inpatients from Wuhan, China.BMI 与代谢不健康状态与 COVID-19 死亡率的关联：基于来自中国武汉的 3019 名住院患者。
Nutr Metab Cardiovasc Dis. 2021 Oct 28;31(11):3219-3226. doi: 10.1016/j.numecd.2021.07.030. Epub 2021 Aug 5.
2
Obesity is associated with severe disease and mortality in patients with coronavirus disease 2019 (COVID-19): a meta-analysis.肥胖与 2019 冠状病毒病（COVID-19）患者的严重疾病和死亡率相关：一项荟萃分析。
BMC Public Health. 2021 Aug 4;21(1):1505. doi: 10.1186/s12889-021-11546-6.
3
Leptin Deficiency, Caused by Malnutrition, Makes You Susceptible to SARS-CoV-2 Infection but Could Offer Protection from Severe COVID-19.由营养不良引起的瘦素缺乏会使你易感染新冠病毒，但可能为严重的新冠肺炎提供保护。
mSphere. 2021 May 12;6(3):e00031-21. doi: 10.1128/mSphere.00031-21.
4
Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?肥胖与病毒感染易感性及严重程度：从流感到 COVID-19 的启示。瘦素是否发挥作用？
Int J Mol Sci. 2021 Mar 20;22(6):3183. doi: 10.3390/ijms22063183.
5
Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid 19.肥胖作为新冠肺炎危重症患者不良结局的一个危险因素。
Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):762-768. doi: 10.1016/j.numecd.2020.11.012. Epub 2020 Nov 20.
6
Obesity as a risk factor for hospitalization in COronaVirus Disease-19 (COVID-19) patients: Analysis of the Tuscany regional database.肥胖作为 COVID-19 患者住院的风险因素：托斯卡纳地区数据库分析。
Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):769-773. doi: 10.1016/j.numecd.2020.11.030. Epub 2020 Dec 8.
7
Leptin correlates with monocytes activation and severe condition in COVID-19 patients.瘦素与 COVID-19 患者的单核细胞激活和严重程度相关。
J Leukoc Biol. 2021 Jul;110(1):9-20. doi: 10.1002/JLB.5HI1020-704R. Epub 2021 Jan 6.
8
The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort.肥胖悖论：来自 SMAtteo COvid-19 REgistry（SMACORE）队列的分析。
Nutr Metab Cardiovasc Dis. 2020 Oct 30;30(11):1920-1925. doi: 10.1016/j.numecd.2020.07.047. Epub 2020 Aug 11.
9
Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue.2019冠状病毒病感染相关呼吸衰竭中的瘦素水平：一项横断面研究及脂肪组织作用的病理生理框架
Heliyon. 2020 Aug;6(8):e04696. doi: 10.1016/j.heliyon.2020.e04696. Epub 2020 Aug 20.
10
COVID-19 Rise in Younger Adults with Obesity: Visceral Adiposity Can Predict the Risk.肥胖的年轻成年人中新冠病毒肺炎（COVID-19）感染率上升：内脏脂肪过多可预测风险。
Obesity (Silver Spring). 2020 Oct;28(10):1795. doi: 10.1002/oby.22951. Epub 2020 Sep 2.

Leptin as a potential prognostic marker of the severity of COVID-19 infection in obese patients.

作者信息

Baltodano-Calle Maria J, Polo-Vasquez Jhoanna S, Romani-Pozo Alina, Gutarra-Saldaña Diego, Guija-Poma Emilio

机构信息

Universidad Peruana Cayetano Heredia Facultad de Medicina, Lima, Peru; Sociedad Científica de Estudiantes De Medicina Cayetano Heredia (SOCEMCH), Lima, Peru.

Universidad Peruana Cayetano Heredia Facultad de Medicina, Lima, Peru; Sociedad Científica de Estudiantes De Medicina Cayetano Heredia (SOCEMCH), Lima, Peru.

出版信息

Nutr Metab Cardiovasc Dis. 2022 Mar;32(3):743-744. doi: 10.1016/j.numecd.2021.12.003. Epub 2021 Dec 10.

DOI:10.1016/j.numecd.2021.12.003
PMID:35109999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8660140/
Abstract
摘要