Stentz Frankie B, Mikhael Andrew, Kineish Omer, Christman John, Sands Chris
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Nutr Metab Cardiovasc Dis. 2021 Apr 9;31(4):1227-1237. doi: 10.1016/j.numecd.2020.11.027. Epub 2020 Dec 8.
High Protein diets may be associated with endocrine responses that favor improved metabolic outcomes. We studied the response to High Protein (HP) versus High Carbohydrate (HC) Diets in terms of incretin hormones GLP-1 and GIP, the hunger hormone ghrelin and BNP, which is associated with cardiac function. We hypothesized that HP diets induce more pronounced release of glucose lowering hormones, suppress hunger and improve cardiac function.
24 obese women and men with prediabetes were recruited and randomized to either a High Protein (HP) (n = 12) or High Carbohydrate (HC) (n = 12) diet for 6 months with all food provided. OGTT and MTT were performed and GLP-1, GIP, Ghrelin, BNP, insulin and glucose were measured at baseline and 6 months on the respective diets. Our studies showed that subjects on the HP diet had 100% remission of prediabetes compared to only 33% on the HC diet with similar weight loss. HP diet subjects had a greater increase in (1) OGTT GLP-1 AUC(p = 0.001) and MTT GLP-1 AUC(p = 0.001), (2) OGTT GIP AUC(p = 0.005) and MTT GIP AUC(p = 0.005), and a greater decrease in OGTT ghrelin AUC(p = 0.005) and MTT ghrelin AUC(p = 0.001) and BNP(p = 0.001) compared to the HC diet at 6 months.
This study demonstrates that the HP diet increases GLP-1 and GIP which may be responsible in part for improved insulin sensitivity and β cell function compared to the HC diet. HP ghrelin results demonstrate the HP diet can reduce hunger more effectively than the HC diet. BNP and other CVRF, metabolic parameters and oxidative stress are significantly improved compared to the HC diet. CLINICALTRIALS.
NCT01642849.
高蛋白饮食可能与有利于改善代谢结果的内分泌反应有关。我们研究了在肠促胰岛素激素胰高血糖素样肽 -1（GLP -1）和葡萄糖依赖性促胰岛素多肽（GIP）、饥饿激素胃饥饿素以及与心脏功能相关的脑钠肽（BNP）方面，高蛋白（HP）饮食与高碳水化合物（HC）饮食的反应。我们假设高蛋白饮食能诱导更显著的降血糖激素释放，抑制饥饿并改善心脏功能。
招募了24名患有糖尿病前期的肥胖女性和男性，并将他们随机分为高蛋白（HP）组（n = 12）或高碳水化合物（HC）组（n = 12），提供所有食物，为期6个月。进行了口服葡萄糖耐量试验（OGTT）和混合餐耐量试验（MTT），并在基线和各自饮食6个月时测量了GLP -1、GIP、胃饥饿素、BNP、胰岛素和葡萄糖。我们的研究表明，与高碳水化合物饮食组仅有33%的糖尿病前期缓解率相比，高蛋白饮食组的糖尿病前期缓解率为100%，且体重减轻情况相似。与高碳水化合物饮食组相比，高蛋白饮食组在6个月时：（1）OGTT的GLP -1曲线下面积（AUC）（p = 0.001）和MTT的GLP -1 AUC（p = 0.001）有更大增加；（2）OGTT的GIP AUC（p = 0.005）和MTT的GIP AUC（p = 0.005）有更大增加，OGTT胃饥饿素AUC（p = 0.005）、MTT胃饥饿素AUC（p = 0.001）和BNP（p = 0.001）有更大下降。
本研究表明，与高碳水化合物饮食相比，高蛋白饮食可增加GLP -1和GIP，这可能部分解释了其胰岛素敏感性和β细胞功能的改善。高蛋白饮食组的胃饥饿素结果表明，高蛋白饮食比高碳水化合物饮食能更有效地减少饥饿感。与高碳水化合物饮食相比，BNP及其他心血管危险因素、代谢参数和氧化应激均有显著改善。临床试验。
NCT01642849。
