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Excessive vitamin B12 and poor outcome in COVID-19 pneumonia.新冠肺炎肺炎中维生素B12过量与不良预后
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Folate and vitamin B12 in older Australians.澳大利亚老年人中的叶酸和维生素B12
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[The levels of folic acid and vitamin B12 in the plasma of patient hospitalized with mental illness (literature review and pilot study].[患有精神疾病住院患者血浆中叶酸和维生素B12的水平（文献综述与初步研究）]
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Trends of folate and vitamin B12 during pregnancy.孕期叶酸和维生素B12的变化趋势。
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High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel.以色列老年人群中维生素B12和叶酸缺乏的高患病率。
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Can J Public Health. 2002 Jul-Aug;93(4):249-53. doi: 10.1007/BF03405010.

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Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit.维生素B12作为一种表皮药物用于调节长新冠相关视觉建构缺陷中的外周血生物标志物。
Sci Rep. 2025 Mar 19;15(1):9438. doi: 10.1038/s41598-025-86637-0.
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Association of vitamin B12, folate, and homocysteine with COVID-19 severity and mortality: A systematic review and meta-analysis.维生素B12、叶酸和同型半胱氨酸与新冠病毒疾病严重程度及死亡率的关联：一项系统评价与荟萃分析
SAGE Open Med. 2024 May 20;12:20503121241253957. doi: 10.1177/20503121241253957. eCollection 2024.
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Nutritional deficiencies that may predispose to long COVID.可能导致长新冠的营养缺乏。
Inflammopharmacology. 2023 Apr;31(2):573-583. doi: 10.1007/s10787-023-01183-3. Epub 2023 Mar 15.
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Potential Role of Certain Biomarkers Such as Vitamin B12, ROS, Albumin, as Early Predictors for Prognosis of COVID-19 Outcomes.某些生物标志物如维生素B12、活性氧、白蛋白作为COVID-19预后早期预测指标的潜在作用。
Medicines (Basel). 2022 Jun 15;9(6):36. doi: 10.3390/medicines9060036.
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COVID-19 and One-Carbon Metabolism.COVID-19 与一碳代谢。
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The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients.微量营养素与恢复期患者的 SARS-CoV-2 特异性抗体之间的关联。
Infection. 2022 Aug;50(4):965-972. doi: 10.1007/s15010-022-01774-2. Epub 2022 Feb 21.
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COVID-19 Pandemic as Risk Factors for Excessive Weight Gain in Pediatrics: The Role of Changes in Nutrition Behavior. A Narrative Review.新型冠状病毒肺炎大流行对儿科体重过度增加的风险因素：营养行为改变的作用。一项叙述性综述。
Nutrients. 2021 Nov 26;13(12):4255. doi: 10.3390/nu13124255.
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The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection.维生素 B12 在病毒感染中的作用：对其与肌肉-肠道-大脑轴关系的综合回顾及其对 SARS-CoV-2 感染的影响。
Nutr Rev. 2022 Feb 10;80(3):561-578. doi: 10.1093/nutrit/nuab092.

本文引用的文献

1
Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections.保持最佳营养状态以维持免疫系统正常运作是预防病毒感染的重要因素。
Nutrients. 2020 Apr 23;12(4):1181. doi: 10.3390/nu12041181.
2
Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands.荷兰一般人群中血浆维生素 B12 浓度与全因死亡率的关系。
JAMA Netw Open. 2020 Jan 3;3(1):e1919274. doi: 10.1001/jamanetworkopen.2019.19274.
3
The Role of Micronutrients in the Infection and Subsequent Response to Hepatitis C Virus.微量营养素在丙型肝炎病毒感染及后续反应中的作用。
Cells. 2019 Jun 17;8(6):603. doi: 10.3390/cells8060603.
4
B vitamins in stroke prevention: time to reconsider.B 族维生素在卒中预防中的作用：是时候重新考虑了。
Lancet Neurol. 2017 Sep;16(9):750-760. doi: 10.1016/S1474-4422(17)30180-1.
5
Increased Vitamin B12 levels are associated with mortality in critically ill medical patients.危重症医学患者维生素 B12 水平升高与死亡率相关。
Clin Nutr. 2012 Feb;31(1):53-9. doi: 10.1016/j.clnu.2011.08.010. Epub 2011 Sep 6.
6
Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness.营养缺乏和促红细胞生成素反应迟钝是危重病贫血的病因。
J Crit Care. 2001 Mar;16(1):36-41. doi: 10.1053/jcrc.2001.21795.

Excessive vitamin B12 and poor outcome in COVID-19 pneumonia.

作者信息

Dalbeni Andrea, Bevilacqua Michele, Teani Isabella, Normelli Ilaria, Mazzaferri Fulvia, Chiarioni Giuseppe

机构信息

Department of Medicine, Section of Internal Medicine and Liver Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

Department of Medicine, Section of Gastroenterology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

出版信息

Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):774-775. doi: 10.1016/j.numecd.2020.12.005. Epub 2020 Dec 11.

DOI:10.1016/j.numecd.2020.12.005
PMID:33549452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7834259/
Abstract
摘要