Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran.
Infection. 2022 Aug;50(4):965-972. doi: 10.1007/s15010-022-01774-2. Epub 2022 Feb 21.
Various micronutrients play key roles in the immune responses to viral infection, antibody synthesis, and susceptibility to infection. This study aimed to investigate the role of micronutrients on the immune responses following SARS-CoV-2 infection.
To evaluate humoral immunity following SARS-CoV-2 infection, the levels of SARS-CoV-2-specific IgM and IgG, as well as the concentrations of different micronutrients, were determined in 36 convalescent COVID-19 patients 60 days after infection. Furthermore, the correlation between biochemical and hematological parameters, clinical features, and the changes in adiposity with SARS-CoV-2 antibodies was evaluated.
Serum IgM and IgG antibodies were detected in 38.8% and 83.3% of recovered patients after 60 days of COVID-19 infection, respectively. The values of SARS-CoV-2-specific IgG were negatively correlated with the number of the platelet. Moreover, the values of SARS-CoV-2-specific IgM were positively correlated with LDH and the vitamin B concentration. Furthermore, a gender-specific association of SARS-CoV-2-specific IgG and IgM with vitamins D as well as with B and zinc was observed. A significant negative correlation was observed between the values of IgG with vitamin D in male participants and a positive correlation was detected between IgG values and B in female participants. Moreover, IgM levels with serum zinc values in females were negatively correlated.
Our study suggests the potential role of micronutrients in gender-specific humoral immunity following SARS-CoV-2 infection. Further studies are required with a greater sample of subjects to substantiate the validity and robustness of our findings.
各种微量营养素在病毒感染的免疫反应、抗体合成以及感染易感性中起着关键作用。本研究旨在探讨微量营养素在 SARS-CoV-2 感染后免疫反应中的作用。
为了评估 SARS-CoV-2 感染后的体液免疫，我们在感染后 60 天测定了 36 例康复的 COVID-19 患者的 SARS-CoV-2 特异性 IgM 和 IgG 水平，以及不同微量营养素的浓度。此外，还评估了生化和血液学参数、临床特征以及与 SARS-CoV-2 抗体变化相关的肥胖变化之间的相关性。
在 COVID-19 感染后 60 天，38.8%的康复患者检测到血清 IgM 抗体，83.3%的康复患者检测到 SARS-CoV-2 特异性 IgG 抗体。SARS-CoV-2 特异性 IgG 的值与血小板的数量呈负相关。此外，SARS-CoV-2 特异性 IgM 的值与 LDH 和维生素 B 的浓度呈正相关。此外，还观察到 SARS-CoV-2 特异性 IgG 和 IgM 与维生素 D 以及 B 和锌在性别特异性方面的关联。在男性参与者中，SARS-CoV-2 特异性 IgG 值与维生素 D 值呈显著负相关，而在女性参与者中，SARS-CoV-2 特异性 IgG 值与 B 值呈正相关。此外，女性血清锌值与 IgM 水平呈负相关。
我们的研究表明，微量营养素在 SARS-CoV-2 感染后的性别特异性体液免疫中可能发挥作用。需要进一步进行具有更大样本量的研究，以证实我们研究结果的有效性和稳健性。
