Smith C M, Steffey E P, Baggot J D, Dunlop C I, Farver T B
Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.
Am J Vet Res. 1988 Jan;49(1):19-22.
Inhalation anesthetics decrease the clearance of some drugs that are eliminated by renal excretion. The purpose of the study reported here was to investigate the effects of halothane anesthesia on the pharmacokinetics and urinary excretion of gentamicin sulfate, using the horse as a model. Using a crossover design, pharmacokinetic values after a single IV dose of gentamicin (4 mg/kg) were compared in halothane-anesthetized and unanesthetized horses. Compared with unanesthetized horses, the anesthetized horses had significant decreases in total body clearance (P less than 0.01) and apparent volume of distribution (P less than 0.05), and a significant increase in half-life (P less than 0.05) of gentamicin.
吸入麻醉药会降低某些经肾脏排泄消除的药物的清除率。本文报道的这项研究的目的是以马为模型，研究氟烷麻醉对硫酸庆大霉素药代动力学和尿排泄的影响。采用交叉设计，比较了氟烷麻醉马和未麻醉马单次静脉注射庆大霉素（4mg/kg）后的药代动力学值。与未麻醉马相比，麻醉马的庆大霉素全身清除率显著降低（P<0.01），表观分布容积显著降低（P<0.05），半衰期显著延长（P<0.05）。
