长非编码 RNA 在子宫内膜生理和病理生理学中的作用。
Long non-coding RNAs in endometrial physiology and pathophysiology.
机构信息
Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA; Department of Obstetrics & Gynecology, University of Kansas Medical Center, Kansas City, KS, USA; Institute for Reproduction and Perinatal Research, Center for Reproductive Sciences, University of Kansas Medical Center, Kansas City, KS, USA.
出版信息
Mol Cell Endocrinol. 2021 Apr 5;525:111190. doi: 10.1016/j.mce.2021.111190. Epub 2021 Feb 4.
Abstract
The endometrium is an essential component of the female uterus which provides the environment for pregnancy establishment and maintenance. Abnormalities of the endometrium not only lead to difficulties in establishing and maintaining pregnancy but also play a causative role in diseases of endometrial origin including endometriosis and endometrial cancer. Non-coding RNAs are proposed to play a role in regulating the genome in both normal endometrial physiology and pathophysiology. In this review, we first provide a general overview of non-coding RNAs and reproductive physiology of the endometrium. We then discuss the role on non-coding RNAs in normal endometrial physiology and pathophysiology of endometrial infertility. We then conclude with non-coding RNAs in the pathophysiology of endometriosis and endometrial cancer.
摘要
子宫内膜是女性子宫的重要组成部分，为妊娠的建立和维持提供了环境。子宫内膜的异常不仅导致妊娠建立和维持困难，而且在子宫内膜来源的疾病中起因果作用，包括子宫内膜异位症和子宫内膜癌。非编码 RNA 被认为在正常子宫内膜生理和病理生理中发挥着调节基因组的作用。在这篇综述中，我们首先提供了非编码 RNA 和子宫内膜生殖生理学的概述。然后我们讨论了非编码 RNA 在子宫内膜不孕的正常子宫内膜生理和病理生理中的作用。最后我们总结了非编码 RNA 在子宫内膜异位症和子宫内膜癌的病理生理中的作用。
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