神经营养因子前体和成熟体在抑郁症中的作用。

The role of pro- and mature neurotrophins in the depression.

机构信息

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

出版信息

Behav Brain Res. 2021 Apr 23;404:113162. doi: 10.1016/j.bbr.2021.113162. Epub 2021 Feb 4.

DOI:10.1016/j.bbr.2021.113162

PMID:33549684

Abstract

Neurotrophic factors, which can provide nutritional support to neurons and neuronal cells, also played an important role in their proliferation and survival. As signaling molecules, it also mediated the learning, memory and other activities in the brain. The latest study shows that neurotrophic factors have diametrically opposing effects of the pro- and mature form through distinct receptors. In this review, we summarize the different forms of neurotrophic factors, related receptors, and the corresponding biological effects. More importantly, we expounded the physiology and pathology mechanisms of brain-derived neurotrophic factor(BDNF)in depression. It is hopefully to provide new idea on the relationship of neurotrophic factors and depression.

摘要

神经营养因子可以为神经元和神经细胞提供营养支持，同时在其增殖和存活中也发挥着重要作用。作为信号分子，它还介导了大脑中的学习、记忆等活动。最新研究表明，神经营养因子通过不同的受体，对前体和成熟形式具有截然相反的作用。在这篇综述中，我们总结了神经营养因子的不同形式、相关受体以及相应的生物学效应。更重要的是，我们阐述了脑源性神经营养因子（BDNF）在抑郁症中的生理和病理机制。希望这能为神经营养因子与抑郁症的关系提供新的思路。