Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Diabetologia. 2021 May;64(5):1007-1015. doi: 10.1007/s00125-021-05391-w. Epub 2021 Feb 6.
Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. In this review we consider the supporting evidence in terms of glucose control and quality of life for presently available closed-loop systems and those in development, including dual-hormone closed-loop systems. We also comment on alternative 'do-it-yourself' closed-loop systems. We remark on issues associated with clinical adoption of these approaches, including training provision, and consider limitations of presently available closed-loop systems and areas for future enhancements to further improve outcomes and reduce the burden of diabetes management.
糖尿病技术的进步使得自动化闭环胰岛素输送系统得以发展。几种混合闭环系统已经商业化，反映了这项不断发展的技术从研究迅速过渡到临床实践，它正在逐渐改变儿童和成人 1 型糖尿病的管理。在这篇综述中，我们根据目前可用的闭环系统和正在开发的系统（包括双激素闭环系统）的血糖控制和生活质量方面的支持证据进行了考虑。我们还对替代的“自己动手”闭环系统进行了评论。我们注意到与这些方法的临床应用相关的问题，包括培训提供，并考虑了目前可用的闭环系统的局限性以及未来改进的领域，以进一步改善结果并减轻糖尿病管理的负担。
